Bishof, Rob (Dr)

Biography

Rob joined Federation University in 2019 as senior lecturer and researcher in the field of biomedical and veterinary sciences at the Berwick campus. Rob is based at the Berwick Campus of the University, and he is currently Program Coordinator for the veterinary and wildlife science degree and Program Coordinator for the Bachelor of Science Honours program.

Rob leads his own research group. His research interests are focused on immune-related conditions, particularly the pathophysiology of airway disease and translational research studies. He pioneered the development of a translational sheep model of allergic asthma that subsequently provided opportunities for commercial development and industry/contract research. Rob has received funding for his research through a broad range of government, philanthropic and commercial sources, and his work has fostered productive links and collaborations with local and international colleagues in both Academia and Industry. This work has helped advance our basic understanding of immune mechanisms of airway disease, and enabled translational studies around the pulmonary delivery of therapeutics using large animal models.

Qualifications

• BAgSci (Hons), The University of Melbourne
• PhD, The University of Melbourne

Teaching areas

• Immunology
• Pharmacology and Toxicology
• Biotechnology Laboratory Techniques
• Research Supervision (undergraduate and postgraduate)

Professional associations

• Australian Society for Immunology
• Victorian Infection and Immunity Network
• Aerosol Society
• American Thoracic Society

Publications (last 5 years)

Rajapaksa A, Do L, Ong D, Sourial M, Veysey D, Beare R, Hughes W, Yang W, Bischof RJ, McDonnell A, Eu P, Yeo LY, Licciardi PV, Mulholland EK (2020). Pulmonary Deposition of radionucleotide-labeled palivizumab: proof-of-concept study. Frontiers in Pharmacology (in press).

Hall NE, Mamrot J, Frampton CMA, Read P, Steele EJ, Bischof RJ, Lindley RA (2020). Deaminase associated single nucleotide variants in blood and saliva-derived exomes from healthy subjects. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 821: manuscript 111705.

Kaminskas LM, Landersdorfer C, Bischof RJ, Beck S, Davies AN, Leong N, Ibrahim J, PhamS, Jain A, Halvarsson A,Hug M, Montgomery B, Surber MW (2019). Pharmacokinetics and safety of pirfenidone after inhaled delivery in sheep: a viable approach to treating idiopathic pulmonary fibrosis. Pharm Res 37: 3. doi: 10.1007/s11095-019-2732-2.

Clifton VL, McDonald M, Morrison JL, Holman SL, Lock MC, Saifa Z, Meakin A, Wooldridge AL, Gatford KL, Wallace MJ, Muhlhausler BS, Bischof RJ, Moss JM (2019). Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma. Placenta 83:33-36. doi: 10.1016/j.placenta.2019.06.380. Epub 2019 Jun 28.

Wooldridge AL, Clifton VL, Moss TJ, Lu H, Jamali M, Agostino S, Muhlhausler BS, Morrison JL, De Matteo R, Wallace MJ, Bischof RJ, Gatford KL (2019). Maternal allergic asthma during pregnancy alters fetal lung and immune development in sheep: potential mechanisms for programming asthma and allergy. J Physiol. 597(16):4251-4262. doi: 10.1113/JP277952. Epub 2019 Jul 3.

Paton MCB, Allison BJ, Fahey MC, Li J, Sutherland AE, Pham Y, Nitsos I, Bischof RJ, Moss TJ, Polglase GR, Jenkin G, Miller SL, McDonald CA (2019). Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep. Pediatr Res 86(2):165-173. doi: 10.1038/s41390-019-0366-z. Epub 2019 Mar 11.

Paton MCB, Allison BJ, Li J, Fahey MC, Sutherland AE, Nitsos I, Bischof RJ, Dean JM, Moss TJM, Polglase GR, Jenkin G, McDonald CA & Miller SL (2018). Human Umbilical Cord Blood Therapy Protects Cerebral White Matter from Systemic LPS Exposure in Preterm Fetal Sheep. Dev Neurosci, 40(3):258-270. doi: 10.1159/000490943. Epub 2018 Sep 4.

Wooldridge AL, Bischof RJ, Liu H, Heinemann GK, Hunter DS, Giles LC, Simmons RA, Lien YC, Lu W, Rabinowitz JD, Kind KL, Owens JA, Clifton VL & Gatford KL (2018). Late gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am J Physiol Regul Integr Comp Physiol, 314(1): R22-R33. doi: 10.1152/ajpregu.00549.2016. Epub 2017 Oct 4.

Inocencio IM, Bischof RJ, Xiang SD, Zhara VA, Nguyen V, Lim T, LaRosa D, Barbuto J, Tolcos M, Plebanski M, Polglase GR & Moss TJ (2017). Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles. Sci Rep, 7(1):14704. doi: 10.1038/s41598-017-13113-9.

Gatford KL, Wooldridge AL, Kind KL, Bischof R & Clifton VL (2017). Pre-birth origins of allergy and asthma (invited review). J Reprod Immunol 123:88-93. doi: 10.1016/j.jri.2017.07.002. Epub 2017 Jul 20. Review.

Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Allison BJ, Bischof R, McDonald CA, Jenkin G & Miller SL (2017). Term vs. preterm cord blood cells for the prevention of preterm brain injury. Pediatr Res 82(6): 1030-1038. doi: 10.1038/pr.2017.170. Epub 2017 Aug 16.

Melville JM, McDonald CA, Bischof RJ, Polglase GR, Lim R, Wallace EM, Jenkin G & MossTJ (2017). Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs. PLoS One 12(3): e0173572. https://doi.org/ 10.1371/journal.pone.0173572.

Landersdorfer CB, Nguyen TH, Lieu LT, Nguyen G, Bischof RJ, Meeusen EN, Li J, Nation RL & McIntosh MP (2016). Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model. Antimicrob Agents Chemother 61(1). pii: e01934-16. doi: 10.1128/AAC.01934-16.

Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Bischof R, Castillo-Melendez M, McDonald CA, Wong FY, Jenkin G & Miller SL (2016). Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells. Exp Neurol 283: 179-87. doi: 10.1016/j.expneurol.2016.06.017.

Ryan GM, Bischof RJ, Enkhbaatar P, McLeod VM, Chan LJ, Jones SA, Owen DJ, Porter CJ & Kaminskas LM (2016). A Comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep. Pharm Res 33: 510-525. doi: 10.1007/s11095-015-1806-z. Epub 2015 Oct 20.

Clifton VL, Moss TJ, Wooldridge AL, Gatford KL, Liravi B, Kim D, Muhlhauser BS, Morrison JL, Davies A, De Matteo R, Wallace MJ & Bischof RJ (2016). Development of an experimental model of maternal allergic asthma during pregnancy. J Physiology, doi: 10.1113/JP270752.

Liravi B, Piedrafita D, Nguyen G & Bischof RJ (2015). Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge. BMC Pulmonary Medicine 15:101, doi: 10.1186/s12890-015-0097-9.

Van Gramberg JL, Bischof RJ, O’Hehir RE, de Veer MJ & Meeusen ENT (2015). The innate response to peanut extract in ovine afferent lymph and its correlation with allergen sensitisation. Immunol Cell Biol 93:533-9. doi: 10.1038/icb.2015.4. Epub 2015 Feb 10.