Wang, Yutang (Dr) - Research

Current Research Project/Students

The effect of renal sympathetic denervation on cardiovascular diseases

  • Current PhD students: Ma S Gawned, Michelle Maier, Helen de Weerd
  • Current Honours students: Ahmed Alramahi, Alexander Cole, Ketura Parker

Consulting and Other Activities

Dr Wang is an editor of the following journals:

  • Austin Journal of Cardiovascular Disease and Atherosclerosis
  • Austin Journal of neurosurgery, ISSN 2381-8972
  • Frontiers in Physiology, ISSN 1664-042X
  • Medicine, ISSN 0025-7974

He is an editorial board member of the following journals:

  • Austin Journal of Neurosurgery
  • Case Reports in Internal Medicine, ISSN 2332-7243
  • Frontiers in Physiology, ISSN 1664-042X
  • Medicine, ISSN 0025-7974

Publications/Conferences

Publications in Peer-reviewed Journals

  1. M Steicke, G Yang, TN Dinh, M Dunster-Jones, O Sargisson, F Ahmady, J Golledge Y Wang. The penetration of methanol into bovine cardiac and hepatic tissues is faster than ethanol and formalin. European Journal of Histochemistry 2018; 62:2880 (impact factor: 2.133).
  2. M Steicke, Y Wang. Comment: Translating Guidelines Into Practice: Interpreting the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk. Annals of Pharmacotherapy. 2018;52(1):91. doi: 10.1177/1060028017732358 (impact factor: 2.059).
  3. C Moran, E Biros, S Krishna, Y Wang, C Tikellis, J Moxon, ME Cooper, P Norman, L Burrell, MC Thomas, and J Golledge. Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin converting enzyme 2. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 doi.org/10.1161/ATVBAHA.117.310129 (impact factor: 5.533).
  4. W Cheng, S Wen,Y Wang, Z Qian, Y Tan, H Li, Y Hou, H Hu, J Golledge, G Yang. The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. Medicine. 2017;96 (50): e8953 (impact factor: 2.306).
  5. Y Wang, K Lim and KM Denton. Editorial: Function of Renal Sympathetic Nerves. Front. Physiol. 2017;8:642. doi: 10.3389/fphys.2017.00642 (impact factor: 4.134).
  6. Y Wang, T Dinh, A Nield, SM Krishna, K Denton and J Golledge.  Renal denervation promotes atherosclerosis in hypertensive apolipoprotein E-deficient mice infused with angiotensin II. Front. Physiol. 2017; 8:215. doi:10.3389/fphys.2017.00215 (Impact factor: 4.134)
  7. CS Moran, SW Seto, SM Krishna, S Sharma, RJ Jose, E Biros, Y Wang, SK Morton, J Golledge. Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis. Sci Rep. 2017;7:43079 (impact factor: 5.228)
  8. SM Krishna, SW Seto, RJ Jose, J Li, SK Morton, E Biros, Y Wang, V Nsengiyumva, JHN Lindeman, GG Loots, CM Rush, JM Craig, J Golledge. The Wnt signalling pathway inhibitor sclerostin inhibits angiotensin II-induced aortic. Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) 2017;37:553-566 (impact factor: 5.533).
  9. Y Wang. Does renal denervation inhibit atherosclerosis in humans? Austin J Cardiovasc Dis Atherosclerosis. 2015; 2(1): 1013
  10. A Cole, S Nankervis, H Chew, M Myers, F Charchar, Y Wang. Does renal sympathetic denervation decrease sympathetic nerve activity? Austin Journal of Neurosurgery. 2015;2(1): 1025
  11. S Krishna, SW Seto, Roby Jose, E Biros, C Moran, Y Wang, P Clancy, J Golledge. A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E deficient mouse. Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) 2015; 35:389-98 (impact factor: 5.533)
  12. Y Wang. Letter by Wang Regarding Article, "Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries" Circulation: Cardiovascular Interventions. 2015;8:e002117 (impact factor: 6.982).
  13. Y Wang, TI Emeto, J Lee, L Marshman, C Moran, S Seto, and J Golledge. Mouse models of intracranial aneurysm. Brain Pathology 2015; 25:237-247 (impact factor: 4.739).
  14. Y Wang. Is isolated systolic hypertension an indication for renal denervation? Frontiers in Physiology 2014;5:505 (impact factor: 3.534).
  15. Y Wang. Ethnicity and sympathetic tone: predictors of the blood-pressure response to renal denervation? Nature Reviews Cardiology 2014; 11:638 (impact factor: 10.154).
  16. Y Wang. Letter by Wang Regarding Article, “Renal Denervation for the Treatment of Cardiovascular High Risk-Hypertension or Beyond?” Circulation Research 2014; 115: e18 (impact factor: 11.089).
  17. Y Wang. Could pathophysiology failure be ruled out? American Journal of Medicine 2014; 127:e29 (impact factor: 5.302).
  18. Y Wang. What is the true incidence of renal artery stenosis after sympathetic denervation? Frontiers in Integrative Physiology 2014; 5:311 (impact factor: 3.534).
  19. Y Wang. Ambulatory blood pressure may be designed as the primary efficacy outcome in clinical trials on renal denervation. International Journal of Cardiology 2014;176:1262–1263 (impact factor: 6.175).
  20. Y Wang. Single-sided renal denervation may be not suitable for patients with significant renal artery stenosis. Clinical Research in Cardiology 2014; 2014;103:950–951 (impact factor: 4.560).
  21. Y Wang, SM Krishna, J Moxon, TN Dinh, RJ Jose, H Yu, J Golledge. Influence of apolipoprotein E, age and aortic site on calcium phosphate induced abdominal aortic aneurysm in mice. Atherosclerosis 2014;235:204–12 (impact factor: 3.794).
  22. Y Wang. Renal denervation for resistant hypertension-the Symplicity HTN-1 study. Lancet 2014; 383:1885 (impact factor: 39.060).
  23. Y Wang. Renal denervation: the Irish experience. Hellenic Journal of Cardiology 2014;55:516 (impact factor: 1.227).
  24. Y Wang. It may be not suitable to perform renal denervation in renal arteries with significant stenosis. International Journal of Cardiology 2014;174:750 (impact factor: 6.175).
  25. Y Wang. Patients with renal artery stenosis may not be suitable for renal denervation. Clinical Research in Cardiology 2014;103:585–586 (impact factor: 4.560).
  26. Y Wang.Limitations in current clinical trials on renal denervation. International Journal of Cardiology 2014; 174:225 (impact factor: 6.175).
  27. Y Wang. Renal artery stenosis may be responsible for the gradual return of high blood pressure after renal denervation. Journal of Clinical Hypertension 2014; 16:313 (impact factor: 2.364).
  28. E Biros, CS Moran, Y Wang, PJ Walker, J Cardinal, J Golledge. MicroRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155. Clinical Science 2014;126:795–803 (impact factor: 4.859).
  29. Y Wang. More research is needed to investigate the effect of denervation on blood pressure. Hypertension 2014;63:e85 (impact factor: 7.632).
  30. Y Wang. It is urgent to investigate predictors of the response of blood pressure to renal denervation. Canadian Journal of Cardiology 2014;30:465.e7 (impact factor: 3.122).
  31. Y Wang, SW Seto and J Golledge. Angiotensin II, sympathetic nerve activity and chronic heart failure. Heart Failure Reviews 2014;19:187–198 (impact factor: 3.200).
  32. Y Shen, NC Ward, JM Hodgson, I. B Puddey, Y Wang, D Zhang, GJ Maghzal, R Stocker, K. D Croft. Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for heme oxygenase-1. Free Radic Biol Med 2013;65:908–915. (impact factor: 5.271).
  33. Y Wang, K Denton, and J Golledge. Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation. Hypertension Research 2013;36:1006–7 (impact factor 2.576).
  34. Y Wang, SW Seto, J Golledge. Therapeutic effects of renal denervation on renal failure. Curr Neurovasc Res 2013;10:172–184 (impact factor: 2.719).
  35. Y Wang and J Golledge. Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems. Curr Neurovasc Res 2013;10:81–89 (impact factor: 2.719).
  36. Y Wang, S Krishna and J Golledge. The calcium chloride-induced rodent model of abdominal aortic aneurysm. Atherosclerosis 2013;226:29–39 (impact factor: 3.794).
  37. Y Wang, C Tikellis, M Thomas and J Golledge. Angiotensin converting enzyme 2 and atherosclerosis. Atherosclerosis 2013;226:3–8 (impact factor: 3.794).
  38. Y Wang, S Krishna, PJ Walker, P Norman and J Golledge. Transforming growth factor-β and abdominal aortic aneurysms. Cardiovasc Pathol 2013;22:126–132 (impact factor: 2.066).
  39. D Changsiri, Y Wang, D Rajbhandari, G Maghzal, W. M Mak, C Woolfe, J Duflou, V Gebski, C. G. dos Remedios, D. S Celermajer and R Stocker. Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.  Critical Care Medicine 2011;39:2678–2683 (impact factor: 6.594).
  40. K Jackman, V. H Brait, Y Wang, GJ Maghzal, H. J Ball, G McKenzie, T. M De Silva, R Stocker and C. G Sobey. Vascular expression, activity and function of indoleamine 2,3-dioxygenase 1 following cerebral ischaemia–reperfusion in mice. Naunyn–Schmiedeberg’s Archives of Pharmacology 2011;383:471–481 (impact factor: 2.631).
  41. K Beck, B. J Wu, J Ni, FS Santiago, K Malabanan, C Li, Y Wang, L. M Khachigian and R Stocker. Interplay between heme oxygenase-1 and the multifunctional transcription factor Yin Yang 1 in the inhibition of intimal hyperplasia. Circulation Research 2010;107:1490–1497 (impact factor: 9.989).
  42. Y Wang. Re: The pathophysiology of preeclampsia: current clinical concepts. Journal of Obstetrics and Gynaecology 2010;30:426–427 (impact factor: 0.546).
  43. Y Wang, H Liu, J. P Stasch, G McKenzie, P. K Witting, D Changsiri, B. J Wu, H. J Ball, S. R Thomas, V Kapoor, D. S Celermajer, A. L Mellor, J. F Keaney, Jr, N. H Hunt and R Stocker. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine 2010;16:279–285 (impact factor: 27.553).This paper has attracted comments in the News and Views in Nature Medicine (Nature Medicine 2010;16:265–267) and in Editor’s Choice section of Science Signaling (Science Signaling 2010;3:ec78).
  44. Y Shen, K. D Croft, J. M Hodgson, R Kyle, Lee I. L, Y Wang, R Stocker, N. C Ward. Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK. Biochemical Pharmacology2012;84:1036–1044 (impact factor: 4.705).
  45. Y Wang, Y Wen, Y Fang, H Pang, Z Guo, L Shi and J Li. Experimental vasoprotection by a novel erythrocyte-derived depressing factor in rats with arterial calcinosis. Vascular Pharmacology 2009;50:65–70 (impact factor: 2.319).
  46. B. J Wu, R. G Midwinter, KC Cassano, K Beck, Y Wang, D Changsiri, J. R Gamble and R Stocker. Heme oxygenase-1 increases endothelial progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2009;29:1537–1542 (impact factor: 6.858).
  47. H Pang, Y Wen, N Ma, Y Wang and L Shi. Protective role of a novel erythrocyte-derived depressing factor on blood vessels of renovascular hypertensive rats. Clinical and Experimental Pharmacology and Physiology 2007;34:393–398 (impact factor: 2.196).
  48. N Ma, Y Wang, Y Wen. Protective effects of an erythrocyte-derived depressing factor on blood vessels of hypertensive diabetic rats. Basic Medical Sciences and Clinics 2004;24:566–569.
  49. Y Wang, Y Wen, N Ma and L Shi. Cardiac protective role of a novel erythrocyte-derived depressing factor on rats and its Ca2+ mechanism. Chinese Science Bulletin 2003;48:2710–2714 (impact factor: 1.319).
  50. Y Wang, Y. Y Wen, L Shi, H Pang, N Ma, Y. Y Fu. Action mechanism of a new erythrocyte-derived depressing factor anti-vascular aging. Central South Pharmacy 2003;1:71–74.
  51. H Pang, Y Wen, L Shi, N Ma and Y Wang. Protective role of a novel human erythrocyte-derived depressing factor on blood vessels in rats. Chinese Science Bulletin 2002;47:717–721 (impact factor: 1.319).
  52. Y Wang, Y Wen, H Pang, L Shi, N Ma. Comparison of the action of human and porcine erythrocyte-derived depressing factor. Acta Academiae Medicinae Sinicae 2002;24:344–348.
  53. Y Wang, H Zheng. Experimental research of Taoxingru Emulsion on injury caused by motor vehicle exhaust gas. Journal of Integrative Medicine 2000;9:2338–2340.
  54. J. R Yuan, R Rong, Y Wang. Research on volatile oil component in szechwan lovge rhizome. Journal of Chinese Medicine 1999;34:406.

Books

  1. Y Wang, K Lim, KM Denton, eds (2017). Function of Renal Sympathetic Nerves. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-295-8
  2. Y Wang, a member of the editorial committee. In: Huzhan Zheng, Zehong Dong and Jing She, eds. Proceedings in Pharmacology of Traditional Chinese Medicine. Beijing: Xue Yuan Press, 1998.

News Paper articles

  1. DR Sullivan and Y Wang. Is saturated fat really the killer it’s made out to be? The Conversation. May 9, 2017. https://theconversation.com/viewpoints-is-saturated-fat-really-the-killer-its-made-out-to-be-76698