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Professor Stuart Berzins

Professor, Immunology

School of Science, Psychology and Sport

Section/Portfolio:

Life Sciences

Location:

Mt Helen Campus, Online

The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence

The plakin family of cytoskeletal proteins play an important role in cancer progression yet are...

A Role for MAIT Cells in Colorectal Cancer

MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties,...

Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity

Langerhans cell histiocytosis (LCH) lesions contain myeloid lineage ‘LCH’ cells. Regulatory T...

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile

Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit...

Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge

T cell lineages are defined by specialized functions and differential expression of surface...

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune...

Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers

Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize antigens...

Divergent SATB1 expression across human life span and tissue compartments

Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating...

Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis

Langerhans cell histiocytosis (LCH) lesions are defined by the presence of CD1a+/CD207+ myeloid...

A potentially important role for T cells and regulatory T cells in Langerhans cell histiocytosis

Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells,...

Human blood MAIT cell subsets defined using MR1 tetramers

Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells....

Temporal regulation of natural killer T cell interferon gamma responses by ?-catenin-dependent and-independent wnt signaling

Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical...

Circulating Mucosal-associated invariant T (MAIT) cells in Chronic Lymphocytic Leukemia (CLL)

No Abstract

  • Journals

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

BACKGROUND: Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular...

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives...

An emerging role for immune regulatory subsets in chronic lymphocytic leukaemia

The last few years has seen the burgeoning of a new category of therapeutics for cancer targeting...

Acute Exercise Leads to Regulation of Telomere-Associated Genes and MicroRNA Expression in Immune Cells

Telomeres are specialized nucleoprotein structures that protect chromosomal ends from...

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy

The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however,...

Natural killer T cells: drivers or passengers in preventing human disease?

Natural killer T (NKT) cells are credited with regulatory roles in immunity against cancers,...

The glucocorticoid receptor 1A3 promoter correlates with high sensitivity to glucocorticoid-induced apoptosis in human lymphocytes

Glucocorticoids (GCs) are powerful inhibitors of inflammation and immunity. Although...

Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4(+) and CD4(-) subsets

Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on...

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

Although the proapoptotic BH3-only protein, Bim, is required for deletion of autoreactive...

The NF-kappa B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

The role of specific members of the NF-kappa B family of transcription factors in CD8 T-cell...

The role of NFkB in T-lymphocyte Development and Function

  • Journals

Presumed guilty: natural killer T cell defects and human disease

Natural killer T (NKT) cells are important regulatory lymphocytes that have been shown in mouse...

An NZW-Derived Interval on Chromosome 7 Moderates Sialadenitis, But Not Insulitis in Congenic Nonobese Diabetic Mice

Autoimmune lymphocytic infiltration of the salivary glands, termed sialadenitis, is a pathologic...

Developing NKT cells need their (E) protein

[No abstract available]

Lessons Learned From an Unusual Presentation of CD3+, CD56- T-Cell Large Granular Lymphocyte Leukemia

Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients

Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by...

Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family

  • Journals

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population

NKT cell development in the absence of the autoimmune regulator gene (Aire)

Control points in NKT-cell development

CD1d-dependent natural killer T (NKT) cells are a unique T-cell subset with the ability to...