Professor Stuart Berzins
Professor, Immunology
Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples
A three-stage developmental pathway for human V?9V?2 T cells within the postnatal thymus
Distinct subpopulations of DN1 thymocytes exhibit preferential gamma delta T lineage potential
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells
Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice
A high-dimensional cytometry atlas of peripheral blood over the human life span
Plasma Signaling Factors in Patients With Langerhans Cell Histiocytosis (LCH) Correlate With Relative Frequencies of LCH Cells and T Cells Within Lesions
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes
Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells
iNKT cells play a critical role in controlling the strength and character of adaptive and innate...
The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence
The plakin family of cytoskeletal proteins play an important role in cancer progression yet are...
A Role for MAIT Cells in Colorectal Cancer
MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties,...
Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity
Langerhans cell histiocytosis (LCH) lesions contain myeloid lineage ‘LCH’ cells. Regulatory T...
High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2(+) T Cell Subset with a MAIT Cell-like Transcriptional Profile
Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit...
Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge
T cell lineages are defined by specialized functions and differential expression of surface...
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune...
Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize antigens...
Divergent SATB1 expression across human life span and tissue compartments
Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer capable of activating...
Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis
Langerhans cell histiocytosis (LCH) lesions are defined by the presence of CD1a+/CD207+ myeloid...
A potentially important role for T cells and regulatory T cells in Langerhans cell histiocytosis
Langerhans cell histiocytosis is characterized by lesions containing inflammatory immune cells,...
Human blood MAIT cell subsets defined using MR1 tetramers
Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells....
Temporal regulation of natural killer T cell interferon gamma responses by ?-catenin-dependent and-independent wnt signaling
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical...
Circulating Mucosal-associated invariant T (MAIT) cells in Chronic Lymphocytic Leukemia (CLL)
No Abstract
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure
BACKGROUND: Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular...
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives...
An emerging role for immune regulatory subsets in chronic lymphocytic leukaemia
The last few years has seen the burgeoning of a new category of therapeutics for cancer targeting...
Acute Exercise Leads to Regulation of Telomere-Associated Genes and MicroRNA Expression in Immune Cells
Telomeres are specialized nucleoprotein structures that protect chromosomal ends from...
Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy
The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however,...
Natural killer T cells: drivers or passengers in preventing human disease?
Natural killer T (NKT) cells are credited with regulatory roles in immunity against cancers,...
The glucocorticoid receptor 1A3 promoter correlates with high sensitivity to glucocorticoid-induced apoptosis in human lymphocytes
Glucocorticoids (GCs) are powerful inhibitors of inflammation and immunity. Although...
Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4(+) and CD4(-) subsets
Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on...
The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens
Although the proapoptotic BH3-only protein, Bim, is required for deletion of autoreactive...
The NF-kappa B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties
The role of specific members of the NF-kappa B family of transcription factors in CD8 T-cell...
The role of NFkB in T-lymphocyte Development and Function
Presumed guilty: natural killer T cell defects and human disease
Natural killer T (NKT) cells are important regulatory lymphocytes that have been shown in mouse...
An NZW-Derived Interval on Chromosome 7 Moderates Sialadenitis, But Not Insulitis in Congenic Nonobese Diabetic Mice
Autoimmune lymphocytic infiltration of the salivary glands, termed sialadenitis, is a pathologic...
Developing NKT cells need their (E) protein
[No abstract available]
Lessons Learned From an Unusual Presentation of CD3+, CD56- T-Cell Large Granular Lymphocyte Leukemia
Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients
Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by...
Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population
NKT cell development in the absence of the autoimmune regulator gene (Aire)
Control points in NKT-cell development
CD1d-dependent natural killer T (NKT) cells are a unique T-cell subset with the ability to...