Dr. Rob Bischof
Senior Lecturer, Infectious Disease
Aerosol Delivery of Palivizumab in a Neonatal Lamb Model of Respiratory Syncytial Virus Infection
Single-dose pharmacokinetics and lung function of nebulized niclosamide ethanolamine in sheep
Liposomes are Poorly Absorbed via Lung Lymph After Inhaled Administration in Sheep
Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma
Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part,...
Aerosol Pirfenidone Pharmacokinetics after Inhaled Delivery in Sheep: a Viable Approach to Treating Idiopathic Pulmonary Fibrosis
Purpose: Inhaled delivery of pirfenidone to the lungs of patients with idiopathic pulmonary...
Blood and saliva-derived exomes from healthy Caucasian subjects do not display overt evidence of somatic mosaicism
Somatic mosaicism is a normal occurrence during development in the tissues and organs. As part of...
Pulmonary Deposition of Radionucleotide-Labeled Palivizumab: Proof-of-Concept Study
Objective: Current prevention and/or treatment options for respiratory syncytial virus (RSV)...
Maternal allergic asthma during pregnancy alters fetal lung and immune development in sheep: potential mechanisms for programming asthma and allergy
Key points: Experimental maternal allergic asthma in sheep provides an experimental model in...
Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma
Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and...
Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep
Background: Chorioamnionitis and fetal inflammation are principal causes of neuropathology...
Human umbilical cord blood therapy protects cerebral white matter from systemic LPS exposure in preterm fetal sheep
Background: Infants born preterm following exposure to in utero inflammation/chorioamnionitis are...
Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR
Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our...
Exacerbation of Ventilation-Induced Lung Injury and Inflammation in Preterm Lambs by High-Dose Nanoparticles
Mechanical ventilation of preterm neonates causes lung inflammation and injury, with potential...
Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs
Ventilation of preterm neonates causes pulmonary inflammation that can contribute to lung injury,...
Pre-birth origins of allergy and asthma
Allergy is a chronic disease that can develop as early as infancy, suggesting that early life...
Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model
Colistin, administered as its inactive prodrug colistin methanesulfonate (CMS), is often used in...
Term vs. preterm cord blood cells for the prevention of preterm brain injury
BACKGROUNDWhite matter brain injury in preterm infants can induce neurodevelopmental deficits....
A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep
Purpose: Cancer metastasis to pulmonary lymph nodes dictates the need to deliver chemotherapeutic...
Development of an experimental model of maternal allergic asthma during pregnancy
Maternal asthma during pregnancy adversely affects pregnancy outcomes but identification of the...
Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells
Infants born very preterm are at high risk for neurological deficits including cerebral palsy. In...
Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge
Background: IL-4 and IL-13 play a critical yet poorly understood role in orchestrating the...
The innate response to peanut extract in ovine afferent lymph and its correlation with allergen sensitisation
The innate response generated after initial allergen exposure is crucial for polarising adaptive...
Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization
Background: Pulmonary-delivered gene therapy promises to mitigate vaccine safety issues and...
Placental restriction of fetal growth reduces cutaneous responses to antigen after sensitization in sheep
Prenatal and early childhood exposures are implicated as causes of allergy, but the effects of...
Stress-induced behavioral and metabolic adaptations lead to an obesity-prone phenotype in ewes with elevated cortisol responses
The underlying cause of predisposition to obesity is complex but one marker is cortisol...
Pulmonary delivery of an ultra-fine oxytocin dry powder formulation: Potential for treatment of postpartum haemorrhage in developing countries
Oxytocin is recommended by the World Health Organisation as the most effective uterotonic for the...
Changes in fetal thymic immune cell populations in a sheep model of intrauterine inflammation
Intrauterine inflammation is a common antecedent of preterm birth and can alter the development...
Induction of Allergic Responses to Peanut Allergen in Sheep
Peanut allergy is the leading cause of deaths due to food-induced anaphylaxis but despite...
Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling
This study aimed to determine whether postprandial temperature excursions in skeletal muscle are...
An ovine tracheal explant culture model for allergic airway inflammation
Background. The airway epithelium is thought to play an important role in the pathogenesis of...