Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma
Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the mainstay...
Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions
The importance of Glucagon like peptide 1 (GLP-1) for metabolic control and insulin release...
Immunohistochemical analysis of pancreatic islets of platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus ssp.)
Monotremes have undergone remarkable changes to their digestive and metabolic control system;...
Cell culture metabolomics in the diagnosis of lung cancer-the influence of cell culture conditions
Lung cancer is the leading cause of cancer deaths. Unfortunately, lung cancer is often diagnosed...
Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past
Contemporary humans are genetically adapted to the environment that their ancestors survived in...
Changes in the ghrelin hormone pathway maybe part of an unusual gastric system in monotremes
Ghrelin is a growth hormone (GH)-releasing and appetite-regulating peptide predominately released...
The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells
Dysfunctional zinc signaling is implicated in disease processes including cardiovascular disease,...
Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus
Zinc is an essential trace element that plays a vital role in maintaining many biological...
Ability of GHTD-amide and analogs to enhance insulin activity through zinc chelation and dispersal of insulin oligomers
GHTD-amide is a tetrapeptide originally isolated from human urine that has hypoglycemic activity....
GHTD-amide: A naturally occurring beta cell-derived peptide with hypoglycemic activity
Dietary Toxins, Endoplasmic Reticulum (ER) Stress and Diebetes
Halting the accelerating epidemic of type 1 diabetes.
Maternal diet during pregnancy and islet autoimmunity in offspring
Background: Recent studies on the etiology of type 1 diabetes mellitus (T1DM) suggest that the...
Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in Î² cells and delays neonatal remodeling of the endocrine pancreas.
A natural occurring tetrapeptide GHTD-amide increases intracellular free zinc in C2C12 myotubes
In utero exposure to the vacuolar-ATPase inhibitor bafilomycin increases susceptibility of pancreatic beta cells to cytokine-induced cell death
Dietary Vacuolar-ATPase Inhibitors as an Environmental Trigger of Type 1 Diabetes
The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas
The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells
In Vivo studies of a novel glucose lowering agent, ISF402
Microphysiometry studies of insulin sensitising factor 402 in C2C12 muscle cells
Transplacental exposure to bafilomycin disrupts pancreatic islet organogenesis and accelerates diabetes onset in NOD mice
In utero exposure to dietary bafilomycin promotes autoimmune diabetes in NOD mice
Islet cell antibody 512 (ICA 512) in patients with IDDM disease