Professor Chris Hutchison
Deputy Vice-Chancellor (Research and Innovation)
N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene
Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA...
Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability
Xenopus LAP2β protein is the single isoform expressed in XTC cells. The protein localizes on...
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage
Lamins A/C have been implicated in DNA damage response pathways. We show that the DNA repair...
B-type lamins in health and disease
For over two decades, B-type lamins were thought to have roles in fundamental processes including...
Delayed self-regulation and timedependent chemical drive leads to novel states in epigenetic landscapes
The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature...
Do lamins influence disease progression in cancer?
For nearly 60 years, diagnosis of cancer has been based on pathological tests that look for...
B-type lamins and their elusive roles in metazoan cell proliferation and senescence
No abstract available
Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures
Human multipotent skin derived precursor cells (SKPs) are traditionally sourced from dissociated...
A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/tmem53 as involved in stress-dependent cell cycle withdrawal
Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein...
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation
Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of...
Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope
Laminin-associated polypeptide 2 (LAP2) proteins are alternatively spliced products of a single...
The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine
Fibroblasts from patients with the severe laminopathy diseases, restrictive dermopathy (RD) and...
The role of DNA damage in laminopathy progeroid syndromes
Progeroid laminopathies are characterized by the abnormal processing of lamin A, the appearance...
The role of lamin A in cytoskeleton organization in colorectal cancer cells: A proteomic investigation
Upregulated expression of lamin A has been implicated in increased cell invasiveness and...
Lamins as cancer biomarkers
Lamins are multifunctional proteins that are often aberrantly expressed or localized in tumours....
Prelamin A processing and functional effects in restrictive dermopathy
No abstract available
A-type lamins, disease and ageing: a stress-induced relationship?
[No abstract available]
Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β-catenin
It is well documented that adipogenic differentiation of the cell is associated with...
Adult stem cell maintenance and tissue regeneration in the ageing context: The role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches
Adult stem cells have been identified in most mammalian tissues of the adult body and are known...
Colonic and colorectal cancer stem cells: Progress in the search for putative biomarkers
The maintenance of healthy colonic crypts is dependent on the integrity of the adult epithelial...
Filaments made from A- and B-type lamins differ in structure and organization
Lamins are intermediate filament proteins and the major component of the nuclear lamina. Current...
Lamin A: A putative colonic epithelial stem cell biomarker which identifies colorectal tumours with a more aggressive phenotype
Abnormalities in the expression, distribution and structural organization of A-type lamins are...
Lamin A/C is a risk biomarker in colorectal cancer
Background: A-type lamins are type V intermediate filament proteins encoded by the gene LMNA....
NEP-A and NEP-B both contribute to nuclear pore formation in Xenopus eggs and oocytes
In vertebrates, the nuclear envelope (NE) assembles and disassembles during mitosis. As the NE is...
A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane
The type II inner nuclear membrane protein emerin is a component of the LINC complex that...
Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts
In human diploid fibroblasts (HDFs), expression of lamina-associated polypeptide 2 α (LAP2α)...
Lamina-associated polypeptide 2α regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway
Lamina-associated polypeptide (LAP) 2α is a non-membrane-bound LAP2 isoform that forms complexes...
Nuclear lamins: Laminopathies and their role in premature ageing
It has been demonstrated that nuclear lamins are important proteins in maintaining cellular as...
The inner nuclear membrane protein Emerin regulates β-catenin activity by restricting its accumulation in the nucleus
Emerin is a type II inner nuclear membrane (INM) protein of unknown function. Emerin function is...
Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay
A major cause of ageing is thought to be the accumulation of damage to macromolecules....
A-type lamins are essential for TGF-β1 induced PP2A to dephosphorylate transcription factors
Diseases caused by mutations in lamins A and C (laminopathies) suggest a crucial role for A-type...
Genomic instability in laminopathy-based premature aging
Premature aging syndromes often result from mutations in nuclear proteins involved in the...
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope
The vertebrate proteins Nesprin-1 and Nesprin-2 (also referred to as Enaptin and NUANCE) together...
Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro
Changes in the expression and distribution of nuclear lamins were investigated during C2C12...
The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene
The authors report the clinical and histologic phenotypes of a LGMD1B family including a newborn...
A-type lamins: Guardians of the soma?
The gene LMNA encodes the proteins lamins A and C and is implicated in nine different...
Laminopathies
Nuclear lamins form a fibrous nucleoskeletal network of intermediate-sized filaments that...
Spectraplakins and nesprins, giant spectrin repeat proteins participating in the organization of the cytoskeleton and the nuclear envelope.
[No abstract available]
The nuclear envelope: a comparative overview.
[No abstract available]
Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma
Background: Aberrant expression patterns of nuclear lamins have been described in various types...
Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes
Nonacoordinate Δ- and Λ-Eu and Tb complexes have been tested as imaging and reactive probes in...
Increased solubility of lamins and redistribution of lamin C in X-linked Emery-Dreifuss muscular dystrophy fibroblasts
Emery-Dreifuss muscular dystrophy (EDMD) is caused by mutations in the gene encoding the nuclear...
Lamin A/C binding protein LAP2α Is required for nuclear anchorage of retinoblastoma protein
The phosphorylation-dependent anchorage of retinoblastoma protein Rb in the nucleus is essential...
Lamins: building blocks or regulators of gene expression?
Intermediate filament (IF) proteins are the building blocks of cytoskeletal filaments, the main...
Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis
Although activated caspase 6 is capable of cleaving both A- and B-type lamins during apoptosis,...
The role of mitotic vesicles in the nuclear assembly.
The nucleus is physically separated from the rest of the cell by the nuclear envelope, which is...
Expression of individual lamins in basal cell carcinomas of the skin
In this study we used a unique collection of type specific anti-lamin antibodies to study lamin...
Lamins in disease: Why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes?
The nuclear lamina is a filamentous structure composed of lamins that supports the inner nuclear...
Functions of the nuclear lamins
The nuclear lamina is a filamentous structure, composed of lamins, that supports the inner...
Head and/or CaaX domain deletions of lamin proteins disrupt preformed lamin A and C but not lamin B structure in mammalian cells
The nuclear lamina is an important determinant of nuclear architecture. Mutations in A-type but...
Incorporation of the nuclear pore basket protein Nup153 into nuclear pore structures is dependent upon lamina assembly: Evidence from cell-free extracts of Xenopus eggs
In cell-free extracts of Xenopus eggs that support the assembly of replication-competent nuclei,...
Lamina-associated polypeptide 2α binds intranuclear A-type lamins
The nucleoskeletal protein lamina-associated polypeptide 2α (LAP2α) contains a large, unique C...
Investigations of the pathway of incorporation and function of lamin A in the nuclear lamina
Cell-free extracts of Xenopus eggs were used to investigate how differing lamin sub-types are...
Temporal differences in the appearance of NEP-B78 and an LBR-like protein during Xenopus nuclear envelope reassembly reflect the ordered recruitment of functionally discrete vesicle types
In this work, we have used novel mAbs against two proteins of the endoplasmic reticulum and outer...