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Dr Sarah Preston

Lecturer, Veterinary Bioscience

School of Science, Psychology and Sport

Section/Portfolio:

Life Sciences

Location:

Mt Helen Campus, Online

Biography

Dr Sarah Preston is an early career academic in animal health, specialising in areas of parasite control and resistance in livestock and companion animals.

Dr Preston’s specific interest are investigating immune response in animals to parasitic worms for the development of breeding diagnostics and vaccines. Sarah is also interested in tracking anthelmintic resistance in livestock. She has over 30 peer-reviewed papers published in these areas.

Sarah has a strong passion for science outreach and science teaching research. She is an active member of the Australian Society for Parasitology (ASP) and works closely with the local community and ASP to develop science activities for National Science Week each year, with successful government funding equalling approximately $70k. She is also evaluating the use of novel technology such as virtual and augmented reality to engage students and teach complex paradigms in animal health.

1-methyl-1H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity

A series of 1-methyl-1H-pyrazole-5-carboxamides were synthesized as potent inhibitors of the...

Advances in the discovery and development of anthelmintics by harnessing natural product scaffolds

Widespread resistance to currently-used anthelmintics represents a major obstacle to controlling...

Comparative evaluation of different molecular methods for DNA extraction from individual Teladorsagia circumcincta nematodes

Abstract Background: The purpose of this study was to develop a reliable DNA extraction protocol...

A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm—Where to from here?

Parasitic roundworms (nematodes) cause substantial morbidity and mortality in animals worldwide....

Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus

Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause...

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

Galectins are a family of glycan-binding molecules with a characteristic affinity for...

DRfit: A Java tool for the analysis of discrete data from multi-well plate assays

Background: Analyses of replicates in sets of discrete data, typically acquired in multi-well...

Identification of fromiamycalin and halaminol a from australian marine sponge extracts with anthelmintic activity against haemonchus contortus

There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic...

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity

A phenotypic screen of two different libraries of small molecules against the motility and...

Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus

Background: Due to anthelmintic resistance problems, there is a need to discover and develop new...

Selected ?-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro

Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to...

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and...

Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro

In the present study, the anthelmintic activity of a human tyrosine kinase inhibitor, AG-1295,...

The current status of anthelmintic resistance in a temperate region of Australia; implications for small ruminant farm management

Widespread anthelmintic resistance in small ruminants is a constraint on the profitability of the...

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

Due to widespread drug resistance in parasitic nematodes, there is a need to develop new...

Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

A phenotypic screen of a diverse library of small molecules for inhibition of the development of...

Proteomic identification of galectin- 11 and 14 ligands from Haemonchus contortus

Haemonchus contortus is the most pathogenic nematode of small ruminants. Infection in sheep and...

Working towards New Drugs against Parasitic Worms in a Public-Development Partnership

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Background: In this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for...

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

As a result of limited classes of anthelmintics and an over-reliance on chemical control, there...

Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus

The control of parasitic roundworms (nematodes) is heavily reliant on the use of a limited number...

Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes

The discovery and development of novel anthelmintic classes is essential to sustain the control...

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus

Background: In partnership with the Medicines for Malaria Venture (MMV), we screened a collection...

Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus

Background: Parasitic roundworms (nematodes) cause substantial morbidity and mortality in...

A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus

High-throughput molecular and computer technologies have become instrumental for systems...

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour

Anthelmintic resistance is widespread in gastrointestinal nematode populations, such that there...

Practical and low cost whole-organism motility assay: A step-by-step protocol

Here, we provide a step-by-step protocol for a practical and low cost whole-organism assay for...

Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

There is a substantial need to develop new medicines against parasitic diseases via...

Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus

Background: Parasitic worms represent a substantial disease burden in animals and humans...

A practical Java tool for small-molecule compound appraisal

Background: The increased use of small-molecule compound screening by new users from a variety of...

Galectin-11: A novel host mediator targeting specific stages of the gastrointestinal nematode parasite, Haemonchus contortus

Galectin-11 is released from epithelial cells of the gastrointestinal tract, specifically...

Low cost whole-organism screening of compounds for anthelmintic activity

Due to major problems with drug resistance in parasitic nematodes of animals, there is a...

Current Status for Gastrointestinal Nematode Diagnosis in Small Ruminants: Where Are We and Where Are We Going?

Gastrointestinal nematode (GIN) parasites pose a significant economic burden particularly in...

Evaluation of the Role of Galectins in Parasite Immunity

Galectin-11 and galectin-14 are ruminant galectins involved in parasitic infections. Although...

The Effect of Different Adjuvants on Immune Parameters and Protection following Vaccination of Sheep with a Larval-Specific Antigen of the Gastrointestinal Nematode, Haemonchus contortus

It has recently been recognised that vaccine adjuvants play a critical role in directing the...