Campus: Mt Helen
Discipline Biomedical Science
Field: Molecular Biology,
Keywords, genetics, human disease
Contact Name: Professor Fadi Charchar Telephone: 61 3 5327 6098
Project 1: The Y chromosome microRNA - a new paradigm of coronary artery disease in men
Supervisors: Prof Fadi Charchar, Prof Stephen Harrap (University of Melbourne)
There is a well-known “male disadvantage” in heart disease – men develop and die of it more frequently than women. The cause of this disparity is still not clear and is not explained by many traditional risk factors such as diet. We have shown in a recent that the male sex Y chromosome is associated with increased risk of heart disease. The current proposed project will utilise molecular techniques to measure the expression of Y genes in patients with CAD. This may improve our understanding of why men are more prone to heart disease and could help to develop sex-specific methods for prevention and treatment of heart disease in the future.
Project 2: Using RNA-Seq to determine the long-non coding RNA profile of hypertensive human kidneys
Supervisors: Prof Fadi Charchar, Dr Maciej Tomaszewski (University of Manchester, UK)
Hypertension is the number one risk factor for many cardiovascular diseases. It is not clear which genes and transcripts are association with increased risk of hypertension. Our hypothesis is that non-coding RNA or/and the aberrant expression of long-non coding RNA (exciting new RNA molecules previously thought of as JUNK RNA) may be one of the drivers. We will be using next generation sequencing and a range of cutting-edge technologies to determine which long non-coding RNA are expressed on the human Kidney.
Prof Fadi Charchar graduated from The University of Melbourne and is currently Chair in Cardiovascular Science at FedUni. His research interests centres on molecular genetics of complex disease. This includes the genetics of cardiovascular diseases, sexual dimorphism of cardiovascular risk and the contribution of changes in genomic structure to disease.