School of Health and Life Sciences

Prof Fadi Charchar

Position: Emeritus Robert HT Smith Chair in Cardiovascular Science
Phone: (03) 5327 6098
Email:f.charchar@federation.edu.au
Room: Y 117

Qualifications

  • BSc (Hons)
  • PhD (Melb)
  • FAHA

Teaching areas

  • Genomics
  • Biomedical research
  • Molecular biology

Professional associations

  • International Society of Hypertension
  • Cardiac Society of Australia and New Zealand
  • European Society of Hypertension
  • American Heart Association

Grants and awards

  • NHMRC - Genetics of Cardiac Hypertrophy
  • NHMRC - Copy Number Variation and Hypertension
  • British Heart Foundation - The Y chromosome and cardiovascular disease
  • National Heart Foundation - Hypertrophy and MicroRNA
  • LEW CARTY Charitable Foundation
  • Helen MacPherson Smith Trust

Research interests

Cardiovascular or heart disease is the predominant cause of human morbidity and mortality in developed countries. A big heart and high blood pressure are bad news, no matter what the cause. These two diseases are both major risk factors for cardiovascular disease and Professor Fadi Charchar's laboratory's effort is devoted to determining the molecular and pathophysiological characteristics of both with the goal of developing novel diagnostic and therapeutic. We are using a model of human heart enlargement that has a genetic cause in collaboration with the University of Melbourne and we also have a large collection of human cohorts and kidney tissue bank in collaboration with universities worldwide. Our recent studies have shown that a novel class of small noncoding RNAs, called microRNAs (miRNAs) are possible contributors to hypertension and enlarged hearts. We are also part of The International Consortium for Blood Pressure Genome-Wide Association Studies (Nature, 2011) We have a special interest in the Y chromosome and disease.

Examples of supervised projects

  1. Non-coding RNA and Cardiovascular Disease
  2. The effect of exercise on telomeres and microRNA
  3. The Y chromosome and heart disease

Publications

  1. Molina E, Chew G. S, Myers S. A, Clarence E. M, Eales J. M, Tomaszewski M, Charchar F. J. A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes. Sci Rep. 2017 Dec 1;7(1):16710.
  2. Chilton W, O'Brien B, Charchar F. J. Telomeres, Aging and Exercise: Guilty by Association?. Int J Mol Sci. 2017 Nov 29;18(12).
  3. Marques F. Z, Prestes P. R, Byars S. G, Ritchie S. C, Wurtz P, Patel S. K, Booth S. A, Rana I, Minoda Y, Berzins S. P, Curl C. L, Bell J. R, Wai B, Srivastava P. M, Kangas A. J, Soininen P, Ruohonen S, Kahonen M, Lehtimaki T, Raitoharju E, Havulinna A, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, McGlynn M, Kelly J, Wlodek M. E, Lewandowski P. A, Delbridge L. M, Burrell L. M, Inouye M, Harrap S. B, Charchar F. J. Experimental and human evidence for lipocalin-2 (neutrophil gelatinase-associated lipocalin [ngal]) in the development of cardiac hypertrophy and heart failure. J Am Heart Assoc. 2017;6
  4. Maan A. A, Eales J, Akbarov A, Rowland J, Xu X, Jobling M. A, Charchar F. J., Tomaszewski M. The Y chromosome: A blueprint for men's health? Eur J Hum Genet. 2017
  5. Harrap S. B, Charchar F. J. Genetics of blood pressure: Time to curate the collection. J Hypertens. 2017
  6. Haitjema S, van Setten J, Eales J, van der Laan SW, Gandin I, de Vries JP, de Borst GJ, Pasterkamp G, Asselbergs FW, Charchar F. J., Wilson J. F, de Jager SC, Tomaszewski M, den Ruijter H. M. Genetic variation within the y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall. Atherosclerosis. 2017;259:114-119
  7. Chilton W. L, O'Brien B. J, Grace F, Charchar F. J. Telomeres, exercise and cardiovascular disease: Finding the means to justify the ends. Acta Physiol (Oxf). 2017;220:186-188
  8. Booth S. A, Charchar F. J. Cardiac telomere length in heart development, function, and disease. Physiol Genomics. 2017;49:368-384
  9. Wise I. A, Charchar F. J. Epigenetic modifications in essential hypertension. Int J Mol Sci. 2016;17:451
  10. Sadiq S, Crowley T. M, Charchar F. J., Sanigorski A, Lewandowski PA. Micrornas in a hypertrophic heart: From foetal life to adulthood. Biol Rev Camb Philos Soc. 2016
  11. Romaine SP, Charchar F. J., Samani NJ, Tomaszewski M. Circulating micrornas and hypertension--from new insights into blood pressure regulation to biomarkers of cardiovascular risk. Curr Opin Pharmacol. 2016;27:1-7
  12. Prestes PR, Marques F. Z, Lopez-Campos G, Booth SA, McGlynn M, Lewandowski P, Delbridge L. M, Harrap SB, Charchar F. J. Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22. J Hypertens. 2016;34:950-958
  13. Molina E, Clarence EM, Ahmady F, Chew G. S, Charchar F. J.. Coronary Artery Disease: Why we should consider the Y Chromosome. Heart, Lung & Circulation. 2016 Jan; doi: http://dx.doi.org/10.1016/j.hlc.2015.12.100
  14. Marques F. Z, Booth SA, Charchar F. J. The emerging role of non-coding RNA in essential hypertension and blood pressure regulation. J Hum Hypertens. 2014 Nov 13. doi: 10.1038/jhh.2014.99
  15. Skommer J, Rana I, Marques F. Z, Zhu W, Du Z,Charchar F. J.. Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death. Cell Death Dis. 2014 Jul 17;5:e1325. doi: 10.1038/cddis.2014.287. Review.
  16. Marques F. Z, Prestes PR, Pinheiro L. B., Scurrah K, Emslie KR, Tomaszewski M, Harrap SB, Charchar F. J. Measurement of absolute copy number variation reveals association with essential hypertension. BMC Med Genomics. 2014 Jul 15;7:44. doi: 10.1186/1755-8794-7-44
  17. Chilton W. L, Marques F. Z, West J, Kannourakis G, Berzins S. P, O'Brien B. J, Charchar F. J. Acute Exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One. 2014 Apr 21;9(4):e92088. doi: 10.1371/journal.pone.0092088.
  18. Bloomer L. D, Nelson C. P, Denniff M, Christofidou P, Debiec R, Thompson J, Zukowska-Szczechowska E, Samani NJ, Charchar F. J, Tomaszewski M. Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids--genetic association analysis. Atherosclerosis. 2014 Mar;233(1):160-4. doi: 10.1016/j.atherosclerosis.2013.12.012.
  19. Kaess B. M, Jóźwiak  J., Nelson C. P., Lukas W., Mastej M., Windak A., Tomasik T., Grzeszczak W., Tykarski A, Gąsowski,  J., Ślęzak-Prochazka, I., Ślęzak, A., Charchar F. J., Sattar N, Thompson J. R, Samani N. J, Tomaszewski M. The relation of rapid changes in obesity measures to lipid profile - insights from a nationwide metabolic health survey in 444 Polish cities. PLoS One. 2014 Jan 31;9(1):e86837. doi: 10.1371/journal.pone.0086837.
  20. Nankervis S. A, Mitchell J. M, Charchar F. J., McGlynn M. A, Lewandowski P. A. Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage. Longevity Healthspan. 2013 Mar 1;2(1):4. doi: 10.1186/2046-2395-2-4.
  21. Debiec R, Christofidou P, Denniff M, Bloomer L. D, Bogdanski P, Wojnar L, Musialik K, Charchar F. J., Thompson J. R, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Samani NJ, Lambert D, Tomaszewski M. Urotensin-II system in genetic control of blood pressure and renal function. PLoS One. 2013 Dec 31;8(12):e83137. doi: 10.1371/journal.pone.0083137.
  22. Burger D, Veerabhadrappa P, Charchar F. J., Schutte AE, Tomaszewski M. Report of the 3rd annual International Society of Hypertension New Investigator Symposium. J Hypertens. 2014 Feb;32(2):448-9. doi: 10.1097/HJH.0000000000000087.
  23. Harrap SB, Charchar F. J. Early treatment to prevent hypertension: a laudable goal. Am J Hypertens. 2013 Dec;26(12):1367-8. doi: 10.1093/ajh/hpt193.
  24. Denham J, Marques F. Z, O'Brien B. J, Charchar F. J. Exercise: putting action into our epigenome. Sports Med. 2014 Feb;44(2):189-209. doi: 10.1007/s40279-013-0114-1.
  25. Marques F. Z, Tomaszewski M, Charchar F. J. Genetic mechanisms of vascular and renal damage. J Hypertens. 2013 Nov;31(11):2128-9. doi: 10.1097/HJH.0b013e3283654187.
  26. Denham J, Nelson C. P, O'Brien B. J, Nankervis S. A, Denniff M, Harvey J. T, Marques F. Z, Codd V, Zukowska-Szczechowska E, Samani N. J, Tomaszewski M, Charchar F. J. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors. PLoS One. 2013 Jul 31;8(7):e69377. doi: 10.1371/journal.pone.0069377.
  27. Jackson K. L, Marques F. Z, Watson A. M, Palma-Rigo K, Nguyen-Huu T. P, Morris B. J, Charchar F. J, Davern P. J, Head G. A. A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice. Hypertension. 2013 Oct;62(4):775-81. doi: 10.1161/HYPERTENSIONAHA.113.01701.
  28. Papazzo A, Conlan X. A, Lexis L, Charchar F. J, Lewandowski P. A. Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction. PLoS One. 2013 Jun 7;8(6):e66655. doi: 10.1371/journal.pone.0066655.
  29. Bloomer L. D, Nelson C. P, Eales J, Denniff M, Christofidou P, Debiec R, Moore J, Consortium C, Zukowska-Szczechowska E, Goodall A. H, Thompson J, Samani N. J, Charchar F. J, Tomaszewski M. Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1722-7. doi: 10.1161/ATVBAHA.113.301608.
  30. Veerabhadrappa P, Charchar F. J, Burger D, Tomaszewski M, Carlberg B. Leading the change: Second International Society of Hypertension New Investigators' Symposium. J Hypertens. 2013 Feb;31(2):429-30. doi: 10.1097/HJH.0b013e32835c552c.
  31. Charchar F. J, Bloomer L. D, Barnes T. A, Cowley M. J, Nelson C. P, Wang Y, Denniff M, Debiec R, Christofidou P, Nankervis S, Dominiczak A. F, Bani-Mustafa A, Balmforth A. J, Hall A. S, Erdmann J, Cambien F, Deloukas P, Hengstenberg C, Packard C, Schunkert H, Ouwehand W. H, Ford I, Goodall A. H, Jobling M. A, Samani N. J, Tomaszewski M. Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet. 2012 Mar 10;379(9819):915-22. doi: 10.1016/S0140-6736(11)61453-0.
  32. Burger D, Veerabhadrappa P, Charchar F. J, Tomaszewski M, Harrap S, Carlberg B, Touyz R. M. Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative. J Hypertens. 2012 Mar;30(3):631-2. doi: 10.1097/HJH.0b013e32834f8267.
  33. Bernardo BC, Charchar F. J, Lin RC, McMullen J. R. A microRNA guide for clinicians and basic scientists: background and experimental techniques. Heart Lung Circ. 2012 Mar;21(3):131-42. doi: 10.1016/j.hlc.2011.11.002.
  34. Veerabhadrappa P, Burger D, Charchar F. J., Tomaszewski M, Carlberg B, Harrap S, Touyz RM. Council for [corrected] High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: [corrected] first New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions. Hypertension. 2012 Feb;59(2):382-3. doi: 10.1161/HYPERTENSIONAHA.111.185421.
  35. Marques F. Z, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang Y. H, Charchar F. J, Morris B. J. Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs. Hypertension. 2011 Dec;58(6):1093-8. doi: 10.1161/HYPERTENSIONAHA.111.180729.
  36. Busst CJ, Bloomer LD, Scurrah KJ, Ellis JA, Barnes TA, Charchar F. J, Braund P, Hopkins P. N, Samani NJ, Hunt SC, Tomaszewski M, Harrap SB. The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses. Hypertension. 2011 Dec;58(6):1073-8. doi: 10.1161/HYPERTENSIONAHA.111.176370.
  37. Chambers J. C, Zhang W, Sehmi J, Li X, Wass M. N, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister S. E, Coin L. J, Deng G, Gieger C, Heard-Costa N. L, Hottenga J. J, Kuhnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal P. M, Mateo Leach I, O'Reilly P. F, Peden J. F, Rahmioglu N, Soininen P, Speliotes E. K, Yuan X, Thorleifsson G, Alizadeh B. Z, Atwood L. D, Borecki I. B, Brown M. J, Charoen P, Cucca F, Das D, de Geus E. J, Dixon A. L, Doring A, Ehret G, Eyjolfsson G. I, Farrall M, Forouhi N. G, Friedrich N, Goessling W, Gudbjartsson D. F, Harris T. B, Hartikainen A. L, Heath S, Hirschfield G. M, Hofman A, Homuth G, Hypponen E, Janssen H. L, Johnson T, Kangas A. J, Kema I. P, Kuhn J. P, Lai S, Lathrop M, Lerch M. M, Li Y, Liang T. J, Lin J. P, Loos R. J, Martin N. G, Moffatt M. F, Montgomery G. W, Munroe P. B, Musunuru K, Nakamura Y, O'Donnell C. J, Olafsson I, Penninx B. W, Pouta A, Prins B. P, Prokopenko I, Puls R, Ruokonen A, Savolainen M. J, Schlessinger D, Schouten J. N, Seedorf U, Sen-Chowdhry S, Siminovitch K. A, Smit J. H, Spector T. D, Tan W, Teslovich T. M, Tukiainen T, Uitterlinden A. G, Van der Klauw M. M, Vasan R. S, Wallace C, Wallaschofski H, Wichmann H. E, Willemsen G, Wurtz P, Xu C, Yerges-Armstrong L. M; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy M. I, Meisinger C, Mooser V, Pietilainen K. H, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas H. C, Thorsteinsdottir U, Uda M, Waeber G, Wareham N. J, Waterworth D. M, Watkins H, Whitfield J. B, Witteman JC, Wolffenbuttel B. H, Fox C. S, Ala-Korpela M, Stefansson K, Vollenweider P, Volzke H, Schadt E. E, Scott J, Jarvelin M. R, Elliott P, Kooner J. S. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970.
  38. International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret G. B, Munroe P. B, Rice K. M, Bochud M, Johnson A. D, Chasman D. I, Smith A. V, Tobin M. D, Verwoert G. C, Hwang S. J, Pihur V, Vollenweider P, O'Reilly P. F, Amin N, Bragg-Gresham J. L, Teumer A, Glazer N. L, Launer L, Zhao J. H, Aulchenko Y, Heath S, Sober S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks A. A, Jackson A. U, Peden J. F, Tanaka T, Wild S. H, Rudan I, Igl W, Milaneschi Y, Parker A. N, Fava C, Chambers J. C, Fox E. R, Kumari M, Go M. J, van der Harst P, Kao W. H, Sjogren M, Vinay D. G, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup P. H, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen K. D, Lehtimaki T, Matullo G, Wu Y, Gaunt T. R, Onland-Moret N. C, Cooper M. N, Platou C. G, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund P. S, Kuznetsova T, Uiterwaal C. S, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer N. D; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium, Aspelund T, Garcia M, Chang Y. P, O'Connell J. R, Steinle N. I, Grobbee D. E, Arking D. E, Kardia S. L, Morrison A. C, Hernandez D, Najjar S, McArdle W. L, Hadley D, Brown M. J, Connell J. M, Hingorani A. D, Day I. N, Lawlor D. A, Beilby J. P, Lawrence R. W, Clarke R, Hopewell J. C, Ongen H, Dreisbach A. W, Li Y, Young J. H, Bis J. C, Kahonen M, Viikari J, Adair L. S, Lee N. R, Chen M. H, Olden M, Pattaro C, Bolton J. A, Kottgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling T. M, Islam M, Jafar T. H, Erdmann J, Kulkarni S. R, Bornstein S. R, Grassler J, Groop L, Voight B. F, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw K. T, Weder A. B, Hunt S. C, Sun Y. V, Bergman R. N, Collins F. S, Bonnycastle L. L, Scott L. J, Stringham H. M, Peltonen L, Perola M, Vartiainen E, Brand S. M, Staessen J. A, Wang T. J, Burton P. R, Soler Artigas M, Dong Y, Snieder H, Wang X, Zhu H, Lohman K. K, Rudock M. E, Heckbert S. R, Smith N. L, Wiggins K. L, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld C. D, Rosengren A, Thelle D. S, Corsi A. M, Singleton A, Forrester T, Hilton G, McKenzie C. A, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann H. E, Cho Y. S, Kim H. L, Lee J. Y, Scott J, Sehmi J. S, Zhang W, Hedblad B, Nilsson P, Smith G. D, Wong A, Narisu N, Stancakova A, Raffel L. J, Yao J, Kathiresan S, O'Donnell C. J, Schwartz S. M, Ikram M. A, Longstreth W. T Jr, Mosley T. H, Seshadri S, Shrine N. R, Wain L. V, Morken M. A, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker S. J, van Gilst W. H, Janipalli C. S, Mani K. R, Yajnik C. S, Hofman A, Mattace-Raso F. U., Oostra B. A, Demirkan A, Isaacs A, Rivadeneira F, Lakatta E. G, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikainen LP, Soininen P, Tukiainen T, Wurtz P, Ong R. T, Dorr M, Kroemer H. K, Volker U, Volzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia J. F, Nalls M. A, Sharma P, Terzic J, Kumar M. V, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FG, Charchar F. J., Schwarz PE, Hayward C, Guo X, Rotimi C, Bots M. L, Brand E, Samani N. J, Polasek O, Talmud P. J, Nyberg F, Kuh D, Laan M, Hveem K, Palmer L. J, van der Schouw YT, Casas J. P, Mohlke K. L, Vineis P, Raitakari O, Ganesh SK, Wong T. Y, Tai E. S, Cooper R. S, Laakso M, Rao DC, Harris TB, Morris R. W, Dominiczak A. F, Kivimaki M, Marmot M. G, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu X, Kooner JS, Melander O, Ridker P. M, Bandinelli S, Gyllensten U. B, Wright A. F, Wilson J. F, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands E. J, Altshuler D, Loos R. J, Shuldiner A. R, Gieger C, Meneton P, Uitterlinden AG, Wareham N. J, Gudnason V, Rotter J. I, Rettig R, Uda M, Strachan D. P, Witteman J. C, Hartikainen A. L, Beckmann JS, Boerwinkle E, Vasan RS, Boehnke M, Larson M. G, Jarvelin M. R, Psaty B. M, Abecasis G. R, Chakravarti A, Elliott P, van Duijn C. M, Newton-Cheh C, Levy D, Caulfield M. J, Johnson T. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. doi: 10.1038/nature10405.
  39. Veerabhadrappa P, Burger D, Carlberg B, Charchar F. J, Tomaszewski M, Harrap S; New Investigators Committee, International Society of Hypertension. ISH Hypertension Future Leaders Group: a network for new investigators run by new investigators. J Hypertens. 2011 Aug;29(8):1664-5. doi: 10.1097/HJH.0b013e3283491598.
  40. Tomaszewski M, Charchar F. J, Nelson C. P, Barnes T, Denniff M, Kaiser M, Debiec R, Christofidou P, Rafelt S, van der Harst P, Wang W. Y, Maric C, Zukowska-Szczechowska E, Samani N. J. Pathway analysis shows association between FGFBP1 and hypertension. J Am Soc Nephrol. 2011 May;22(5):947-55. doi: 10.1681/ASN.2010080829.
  41. Fox E. R, Young J. H, Li Y, Dreisbach A. W, Keating B. J, Musani S. K, Liu K, Morrison A. C, Ganesh S, Kutlar A, Ramachandran V. S, Polak J. F, Fabsitz R. R, Dries D. L, Farlow D. N, Redline S, Adeyemo A, Hirschorn J. N, Sun Y. V, Wyatt S. B, Penman A. D, Palmas W, Rotter J. I, Townsend R. R, Doumatey A. P, Tayo B. O, Mosley T. H Jr, Lyon H. N, Kang S. J, Rotimi C. N, Cooper R. S, Franceschini N, Curb J. D, Martin L. W, Eaton C. B, Kardia S. L, Taylor H. A, Caulfield M. J, Ehret G. B, Johnson T; International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1;20(11):2273-84. doi: 10.1093/hmg/ddr092.
  42. Tomaszewski M, Debiec R, Braund P. S, Nelson C. P, Hardwick R, Christofidou P, Denniff M, Codd V, Rafelt S, van der Harst P, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Burton P. R, Mooser V, Charchar F. J, Thompson J. R, Tobin M. D, Samani N. J. Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension. 2010 Dec;56(6):1069-76. doi: 10.1161/HYPERTENSIONAHA.110.155721.
  43. Kaess B. M, Barnes T. A, Stark K, Charchar F. J, Waterworth D, Song K, Wang W. Y, Vollenweider P, Waeber G, Mooser V, Zukowska-Szczechowska E, Samani N. J, Hengstenberg C, Tomaszewski M. FGF21 signalling pathway and metabolic traits - genetic association analysis. Eur J Hum Genet. 2010 Dec;18(12):1344-8. doi: 10.1038/ejhg.2010.130.
  44. Charchar F. J, Kaiser M, Bingham A. J, Fotinatos N, Ahmady F, Tomaszewski M, Samani N. J. Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure. Hypertension. 2010 May;55(5):1231-8. doi: 10.1161/HYPERTENSIONAHA.109.141663.
  45. Tomaszewski M, Charchar F. J, Barnes T, Gawron-Kiszka M, Sedkowska A, Podolecka E, Kowalczyk J, Rathbone W, Kalarus Z, Grzeszczak W, Goodall A. H, Samani N. J, Zukowska-Szczechowska E. A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1316-21. doi: 10.1161/ATVBAHA.109.185355.
  46. Tomaszewski M, Charchar F. J, Maric C, Kuzniewicz R, Gola M, Grzeszczak W, Samani N. J, Zukowska-Szczechowska E. Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study. Am J Hypertens. 2009 Jan;22(1):100-5. doi: 10.1038/ajh.2008.307.
  47. Caulfield M. J, Munroe P. B, O'Neill D, Witkowska K,Charchar F. J, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson R. J, Wallace C, Newhouse S. J, Brown M, Connell J. M, Dominiczak A, Farrall M, Lathrop G. M, Samani N. J, Kumari M, Marmot M, Brunner E, Chambers J, Elliott P, Kooner J, Laan M, Org E, Veldre G, Viigimaa M, Cappuccio F. P, Ji C, Iacone R, Strazzullo P, Moley K. H, Cheeseman C. SLC2A9 is a high-capacity urate transporter in humans. PLoS Med. 2008 Oct 7;5(10):e197. doi: 10.1371/journal.pmed.0050197.
  48. Tomaszewski M, Charchar F. J, Maric C, Kuzniewicz R, Gola M, Grzeszczak W, Samani N. J, Zukowska-Szczechowska E. Association between lipid profile and circulating concentrations of estrogens in young men. Atherosclerosis. 2009 Mar;203(1):257-62. doi: 10.1016/j.atherosclerosis.2008.06.002.
  49. Tomaszewski M, Charchar F. J, Lynch M. D, Padmanabhan S, Wang W. Y, Miller W. H, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak A. F. Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation. 2007 Oct 23;116(17):1915-24.
  50. Clemitson J. R, Dixon R. J, Haines S, Bingham A. J, Patel B. R, Hall L, Lo M, Sassard J, Charchar F. J, Samani N. J. Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene. Circ Res. 2007 Apr 13;100(7):992-9.
  51. Shankar R. R, Charchar F. J, Eckert G. J, Saha C, Tu W, Dominiczak A. F, Pratt J. H. Studies of an association in boys of blood pressure and the Y chromosome. Am J Hypertens. 2007 Jan;20(1):27-31.
  52. Tomaszewski M, Moreno M. U, Charchar F. J, Zukowska-Szczechowska E, Dominiczak A. F. Functional significance of single nucleotide polymorphisms within the 5'-flanking region of beta2-adrenergic receptor gene. J Hypertens. 2006 Dec;24(12):2473-4.
  53. Tomaszewski M, Zimmerli L, Charchar F. J, Dominiczak A. F. Genetic information in the diagnosis and treatment of hypertension. Curr Hypertens Rep. 2006 Aug;8(4):309-16. Review.
  54. Strahorn P, Graham D, Charchar F. J, Sattar N, McBride M. W, Dominiczak A. F. Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. J Hypertens. 2005 Dec;23(12):2179-86.
  55. Tomaszewski M, Charchar F. J, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak A. F. Letter re: Inflammation and lipoprotein changes with protracted exercise. J Clin Endocrinol Metab. 2005 Aug;90(8):4981.
  56. Dominiczak A. F, Brain N, Charchar F. J, McBride M, Hanlon N, Lee W. K. Genetics of hypertension: lessons learnt from mendelian and polygenic syndromes. Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):611-20. Review.
  57. Dominiczak A. F, Graham D, McBride M. W, Brain N. J, Lee W. K, Charchar F. J, Tomaszewski M, Delles C, Hamilton C. A. Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension. 2005 Apr;45(4):636-42.
  58. Tomaszewski M, Charchar F. J, Lacka B, Pesonen U, Wang W. Y, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak A. F. Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Hypertension. 2004 Nov;44(5):689-94.
  59. Tomaszewski M, Charchar F. J, Crawford L, Zukowska-Sczechowska E, Grzeszczak W, Sattar N, Dominiczak A. F. Serum C-reactive protein and lipids in ultra-Marathon runners. Am J Cardiol. 2004 Jul 1;94(1):125-6.
  60. Charchar F. J, Tomaszewski M, Lacka B, Zakrzewski J, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak A. F. Association of the human Y chromosome with cholesterol levels in the general population. Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):308-12.
  61. McBride M. W, Charchar F. J, Graham D, Miller W. H, Strahorn P, Carr F. J, Dominiczak A. F. Functional genomics in rodent models of hypertension. J Physiol. 2004 Jan 1;554(Pt 1):56-63. Review.
  62. Tomaszewski M, Charchar F. J, Przybycin M, Crawford L, Wallace A. M, Gosek K, Lowe G. D, Zukowska-Szczechowska E, Grzeszczak W, Sattar N, Dominiczak A. F. Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go? Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1640-4.
  63. Charchar F. J, Tomaszewski M, Strahorn P, Champagne B, Dominiczak A. F. Y is there a risk to being male? Trends Endocrinol Metab. 2003 May-Jun;14(4):163-8. Review.
  64. Chapman M. A, Charchar F. J, Kinston S, Bird C. P, Grafham D, Rogers J, Grutzner F, Graves J. A, Green A. R, Gottgens B. Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting. Genomics. 2003 Mar;81(3):249-59.
  65. McBride M. W, Carr F. J, Graham D, Anderson N. H, Clark J. S, Lee W. K, Charchar F. J, Brosnan M. J, Dominiczak A. F. Microarray analysis of rat chromosome 2 congenic strains. Hypertension. 2003 Mar;41(3 Pt 2):847-53.
  66. Charchar F. J, Svartman M, El-Mogharbel N, Ventura M, Kirby P, Matarazzo M. R, Ciccodicola A, Rocchi M, D'Esposito M, Graves J. A. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Genome Res. 2003 Feb;13(2):281-6.
  67. Tomaszewski M, Brain N. J, Charchar F. J, Wang W. Y, Lacka B, Padmanabahn S, Clark J. S, Anderson N. H, Edwards H. V, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak A. F. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension. 2002 Sep;40(3):286-91.
  68. Carr F. J, McBride M. W, Carswell H. V., Graham D, Strahorn P, Clark J. S, Charchar F. J, Dominiczak A. F. Genetic aspects of stroke: human and experimental studies. J Cereb Blood Flow Metab. 2002 Jul;22(7):767-73. Review.
  69. McBride M. W, Carswell H. V, Graham D, Carr F. J,Charchar F. J, Macrae I. M, Dominiczak A. F. Genetic and gender determinants of cerebrovascular disease. Semin Nephrol. 2002 Mar;22(2):127-34. Review.
  70. Charchar F. J, Tomaszewski M, Padmanabhan S, Lacka B, Upton M. N, Inglis G. C, Anderson N. H, McConnachie A, Zukowska-Szczechowska E, Grzeszczak W, Connell J. M, Watt G. C, Dominiczak A. F. The Y chromosome effect on blood pressure in two European populations. Hypertension. 2002 Feb;39(2 Pt 2):353-6.