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Professor Fadi Charchar

Director, Health Innovation and Translation Centre (HITC)

HITC

Section/Portfolio:

HITC

Location:

Mt Helen Campus, Online

Adjustment for body mass index changes inverse associations of HDL-cholesterol with blood pressure and hypertension to positive associations

The associations between high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP) or...

A Modified MTS Proliferation Assay for Suspended Cells to Avoid the Interference by Hydralazine and ?-Mercaptoethanol

The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium...

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

Background: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular...

Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting

Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to...

Prospective meta-analysis protocol on randomised trials of renin-angiotensin system inhibitors in patients with COVID-19: An initiative of the International Society of Hypertension

Introduction Whether ACE inhibitors (ACEi) or angiotensin II receptor blocker (ARB) therapy...

Reduced renal function may explain the higher prevalence of hyperuricemia in older people

This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia...

Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney

The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and...

2020 International Society of Hypertension Global Hypertension Practice Guidelines

[No abstract available]

A guide to the short, long and circular RNAs in hypertension and cardiovascular disease

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in...

An Improved 3-(4,5-Dimethylthiazol-2-yl)-5-(3-Carboxymethoxyphenyl)-2-(4-Sulfophenyl)-2H-Tetrazolium Proliferation Assay to Overcome the Interference of Hydralazine

The MTS...

A year in the life of the EU-CardioRNA COST action: CA17129 catalysing transcriptomics research in cardiovascular disease

The EU-CardioRNA Cooperation in Science and Technology (COST) Action is a European-wide...

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele...

DNA copy number variations - Do these big mutations have a big effect on cardiovascular risk?

[No abstract available]

Highlights from the International Society of Hypertension's New Investigators Network during 2019

The New Investigators Committee (NIC) of the International Society of Hypertension (ISH) is a...

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney

AIMS: Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute...

Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population

Hyperuricemia has been associated with hypertension, however, whether this association exists...

May measurement month 2019: The global blood pressure screening campaign of the international society of hypertension

Elevated blood pressure remains the single biggest risk factor contributing to the global burden...

Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice

BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic nervous...

Reply

[No abstract available]

The association between selected molecular biomarkers and ambulatory blood pressure patterns in African chronic kidney disease and hypertensive patients compared with normotensive controls: Protocol for a longitudinal study

Background: Chronic kidney disease (CKD) is a burgeoning epidemic in sub-Saharan Africa. Abnormal...

The prevalence of cardiovascular risk factors and cardiovascular disease among primary care patients in Poland: results from the LIPIDOGRAM2015 study

Background and aim: To estimate the prevalence of cardiovascular (CV) disease and CV risk factors...

Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis

Objective: The male-specific region of the Y chromosome (MSY) remains one of the most unexplored...

May Measurement Month 2017: Results of 39 national blood pressure screening programmes

Raised blood pressure is the biggest single risk factor responsible for mortality worldwide....

May measurement month 2018: A pragmatic global screening campaign to raise awareness of blood pressure by the international society of hypertension

Aims: Raised blood pressure (BP) is the biggest contributor to mortality and disease burden...

Renal nerves contribute to hypertension in Schlager BPH/2J mice

Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous...

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure...

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic...

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics

Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is...

Are the American Heart Association/American college of cardiology high blood pressure guidelines fit for global purpose? Thoughts from the international society of hypertension

On the basis of currently available evidence, 1. We welcome the increased emphasis on...

Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies

Background: Even before the onset of age-related diseases, obesity might be a contributing factor...

Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive-a new preclinical model

Background--Among the growing numbers of patients with heart failure, up to one half have heart...

Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life

Background and aims: Fetal and postnatal growth restriction cause a predisposition to...

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy

Hypertrophic cardiomyopathy thickens heart muscles, reducing functionality and increasing risk of...

May Measurement Month 2017: an analysis of blood pressure screening results worldwide

Background: Increased blood pressure is the biggest contributor to the global burden of disease...

Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney...

A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes

There is an increasing appreciation for the role of the human Y chromosome in phenotypic...

Cardiac telomere length in heart development, function, and disease

Telomeres are repetitive nucleoprotein structures at chromosome ends, and a decrease in the...

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

Circular RNAs in heart failure

Cardiovascular disease, and particularly heart failure, is still a serious health care issue for...

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

BACKGROUND: Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular...

Genetics of blood pressure: Time to curate the collection

Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall

Background and aims Haplogroup I, a common European paternal lineage of the Y chromosome, is...

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease...

Is there a link between mitochondrial DNA and blood pressure?

[No abstract available]

Liraglutide and Renal Outcomes in Type 2 Diabetes

BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide...

MicroRNAs in a hypertrophic heart: from foetal life to adulthood

The heart is the first organ to form and undergoes adaptive remodelling with age. Ventricular...

Telomeres, aging and exercise: Guilty by association?

Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA...

Telomeres, exercise and cardiovascular disease: finding the means to justify the ends

The y chromosome: A blueprint for men's health?

The Y chromosome has long been considered a genetic wasteland' on a trajectory to completely...

Age-related macular degeneration displays shortened telomere length indicating differential biological aging

No Abstract

  • Journals

A multi-omics glimpse into the biology of arterial stiffness

Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness

Endurance exercise improves cardiovascular health and reduces mortality risk. Augmentation index...

Circulating microRNAs and hypertension - from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Hypertension is a leading cause of cardiovascular morbidity and mortality worldwide, yet the...

Coronary Artery Disease: Why We should Consider the Y Chromosome

Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality globally....

Epigenetic changes in leukocytes after 8 weeks of resistance exercise training

Purpose Regular engagement in resistance exercise training elicits many health benefits including...

Epigenetic Modifications in Essential Hypertension

Essential hypertension (EH) is a complex, polygenic condition with no single causative agent....

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate defines chronic kidney disease and is associated with...

Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres

Leukocyte telomeres shorten with age, and excessive shortening is associated with age-related...

KIDNEY TARGETED microRNA-181a MIMIC TREATMENT IN HYPERTENSIVE BPH/2J MICE

No Abstract

  • Journals

Telomere dynamics during aging in polygenic left ventricular hypertrophy

Short telomeres are associated with increased risk of cardiovascular disease. Here we studied...

Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training

Telomeres are tandem repeat DNA sequences located at distal ends of chromosomes that protect...

THE EFFECT OF GENES INVOLVED IN MONOGENIC HUMAN CARDIOMYOPATHIES IN A POLYGENIC MODEL OF CARDIAC HYPERTROPHY

NO Abstract

  • Journals

THE RENOPROTECTIVE ROLE OF MICRORNAS FROM FIBROSIS CAUSED BY UREMIC TOXINS AFTER MYOCARDIAL INFARCTION

No Abstract

  • Journals

Tripartitemotif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22

Background:Left ventricular (LV) hypertrophy is a risk factor for cardiovascular death, but the...

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are...

Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise

Physical exercise has proven cardiovascular benefits, yet there is no clear understanding of the...

Contribution of microRNA to pathological fibrosis in cardiorenal syndrome: impact of uremic toxins

Progressive reduction in kidney function in patients following myocardial infarction (MI) is...

Editorial: Across the globe in 4months: Two International Society of Hypertension new investigator symposia in 2014

EFFECT OF RENAL DENERVATION ON BLOOD PRESSURE AND MICRORNA 181A IN HYPERTENSIVE SCHLAGER MICE

Objective: Hypertensive Schlager mice (BPH) are hypertensive due to an exaggerated contribution...

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity...

Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans

Aim: DNA methylation programs gene expression and is involved in numerous biological processes....

MicroRNAs in essential hypertension and blood pressure regulation

MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic...

Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure

The fibroblast growth factor 1 (FGF1) gene is expressed primarily in the kidney and may...

Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages

Runs of homozygosity (ROHs) are recognized signature of recessive inheritance. Contributions of...

Signatures of miR-181a on the Renal Transcriptome and Blood Pressure

MicroRNA-181a binds to the 3' untranslated region of messenger RNA (mRNA) for renin, a...

The emerging role of non-coding RNA in essential hypertension and blood pressure regulation

Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be...

Acute Exercise Leads to Regulation of Telomere-Associated Genes and MicroRNA Expression in Immune Cells

Telomeres are specialized nucleoprotein structures that protect chromosomal ends from...

Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis

Objective: Amongst middle-aged men, haplogroup I is associated with approximate to 50% higher...

Exercise: Putting Action into Our Epigenome

Most human phenotypes are influenced by a combination of genomic and environmental factors....

Leukocyte telomere length variation due to DNA extraction method

BACKGROUND: Telomere length is indicative of biological age. Shorter telomeres have been...

Measurement of absolute copy number variation reveals association with essential hypertension

Background: The role of copy number variation (CNV) has been poorly explored in essential...

Report of the 3rd annual International Society of Hypertension New Investigator Symposium.

Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death

MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranscriptional...

The Relation of Rapid Changes in Obesity Measures to Lipid Profile - Insights from a Nationwide Metabolic Health Survey in 444 Polish Cities

Objective: The impact of fast changes in obesity indices on other measures of metabolic health is...

A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice

Genetically hypertensive mice (BPH/2J) are hypertensive because of an exaggerated contribution of...

Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage

BACKGROUND: Caloric restriction is known to extend the lifespan of all organisms in which it has...

  • Journals

Early treatment to prevent hypertension: A laudable goal

[No abstract available]

Genetic mechanisms of vascular and renal damage

[No abstract available]

Leading the change: Second International Society of Hypertension New Investigators' Symposium

Longer Leukocyte Telomeres Are Associated with Ultra-Endurance Exercise Independent of Cardiovascular Risk Factors

Telomere length is recognized as a marker of biological age, and shorter mean leukocyte telomere...

Male-Specific Region of the Y Chromosome and Cardiovascular Risk: Phylogenetic Analysis and Gene Expression Studies

Objective Haplogroup I of male-specific region of the human Y chromosome is associated with 50%...

Salt Loading in Canola Oil Fed SHRSP Rats Induces Endothelial Dysfunction

This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt...

Urotensin-II System in Genetic Control of Blood Pressure and Renal Function

Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised...

A MicroRNA Guide for Clinicians and Basic Scientists: Background and Experimental Techniques

MicroRNAs (miRNAs) are short non-coding RNA molecules that are approximately 22 nucleotides in...

Authors' reply

[No abstract available]

Editorial: Council for high blood pressure research/InterAmerican Society of Hypertension/International Society of Hypertension: First new investigators symposium at the High Blood Pressure Research 2011 scientific sessions

Editorial: Report of the first International Society of Hypertension (ISH) Trainee/new investigator symposium: A global hypertension initiative

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

Background A sexual dimorphism exists in the incidence and prevalence of coronary artery...

Telomere attrition is attenuated in ultra-marathon runners

The acute effects of intense cardiorespiratory exercise on human telomerase reverse transcriptase and sirtuin 6 expression in white blood cells

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet,...

Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs

The kidney has long been invoked in the etiology of essential hypertension. This could involve...

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive...

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We...

ISH Hypertension Future Leaders Group: A network for new investigators run by new investigators

[No abstract available]

Pathway Analysis Shows Association between FGFBP1 and Hypertension

Variants in the gene encoding fibroblast growth factor 1 (FGF1) co-segregate with familial...

The epithelial sodium channel γ-subunit gene and blood pressure: Family based association, renal gene expression, and physiological analyses

Variants in the gene encoding the gamma-subunit of the epithelial sodium channel (SCNN1G) are...

FGF21 signalling pathway and metabolic traits - genetic association analysis.

Fibroblast growth factor 21 (FGF21) is a novel master regulator of metabolic profile. The...

Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array.

Genetic determinants of blood pressure are poorly defined. We undertook a large-scale,...

Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure

Copy number variation has emerged recently as an important genetic mechanism leading to...

A Common Variant in Low-Density Lipoprotein Receptior Related Protein 6 Gene (LRP6) Is Associated with LDL-Cholesterol

OBJECTIVE-: A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was...

Association between lipid profile and circulating concentrations of estrogens in young men

  • Journals

Inverse Associations Between Androgens and Renal Function:The Young Men Cardiovascular Association(YMCA) Study

Background: Men exhibit higher risk of nondiabetic renal diseases than women. This male...

SLC2A9 is a high-capacity urate transporter in humans.

  • Journals

The pressure of finding human hypertension genes: New tools, old dilemmas

Researchers in hypertension genetics feel like they are left behind again. It always seems that...

Association studies in current cardiovascular genetics: functional variants, tags or both?

  • Journals

Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis.

  • Journals

Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene.

  • Journals

Glomerular hyperfiltration: a new marker of metabolic risk

Genetic information in the diagnosis and treatment of hypertension.

  • Journals

Genetics of human essential hypertension from single mutations to quantitative trait loci

  • Book Chapters

Cardiovascular genomics and oxidative stress.

  • Journals

Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat.

  • Journals

Hypertension genetics under pressure

  • Book Chapters

Association of the human Y chromosome with cholesterol levels in the general population.

  • Journals

Epistatic interaction between beta(2)-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension

  • Journals

Functional genomics in rodent models of hypertension.

Genetics of hypertension: lessons learnt from mendelian and polygenic syndromes.

Serum C-reactive protein and lipids in ultra-marathon runners

Cardiovascular diseases and G-protein beta3 subunit gene (GNB3) in the era of genomewide scans

  • Journals

Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting.

Complex events in the evolution of the human pseudoautosomal region 2 (PAR2).

  • Journals

Microarray analysis of rat chromosome 2 congenic strains

  • Journals

Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go?

  • Journals

Y is there a risk to being male?