Professor Fadi Charchar
Director, Health Innovation and Transformation Centre (HITC)
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension
2022 World Hypertension League, Resolve To Save Lives and International Society of Hypertension dietary sodium (salt) global call to action
Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension
Dietary fatty acids and mortality risk from heart disease in US adults: an analysis based on NHANES
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies
Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
Metabolic syndrome is associated with similar long-term prognosis in those living with and without obesity: an analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004-2015 studies
Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies
Transforming global approaches to chronic disease prevention and management across the lifespan: integrating genomics, behavior change, and digital health solutions
Adjustment for body mass index changes inverse associations of HDL-cholesterol with blood pressure and hypertension to positive associations
The associations between high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP) or...
Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population: a nationwide observational, cross-sectional study
Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics
Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies
Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications
Reduction of salt intake: time for more action
Relationship Between Anti-DFS70 Autoantibodies and Oxidative Stress
Renin-Angiotensin System Inhibitors in Patients With COVID-19: A Meta-Analysis of Randomized Controlled Trials Led by the International Society of Hypertension
Telomere therapy for chronic kidney disease
A Modified MTS Proliferation Assay for Suspended Cells to Avoid the Interference by Hydralazine and ?-Mercaptoethanol
The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium...
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure
MicroRNA miR-181a is downregulated in the kidneys of hypertensive patients and hypertensive mice....
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Background: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular...
Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys
Men have higher circulating levels of uric acid than women. This sex difference is suspected to...
Exercise, epigenetics, and aging
Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population
Hyperuricemia has been associated with hypertension, however, whether this association exists...
Noncoding Genes on Sex Chromosomes and Their Function in Sex Determination, Dosage Compensation, Male Traits, and Diseases
Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to...
Plasma proteomics of renal function: A transethnic meta-analysis and mendelian randomization study
Background Studies on the relationship between renal function and the human plasma proteome have...
Prospective meta-analysis protocol on randomised trials of renin-angiotensin system inhibitors in patients with COVID-19: An initiative of the International Society of Hypertension
Introduction Whether ACE inhibitors (ACEi) or angiotensin II receptor blocker (ARB) therapy...
Reduced renal function may explain the higher prevalence of hyperuricemia in older people
This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia...
Secondary stroke prevention in polish adults: Results from the lipidogram2015 study
Background: The purpose of the study was to evaluate secondary stroke prevention in Poland and...
The differences in the prevalence of cardiovascular disease, its risk factors, and achievement of therapeutic goals among urban and rural primary care patients in Poland: Results from the LIPIDOGRAM 2015 study
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and...
2020 International Society of Hypertension Global Hypertension Practice Guidelines
[No abstract available]
A guide to the short, long and circular RNAs in hypertension and cardiovascular disease
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in...
An Improved 3-(4,5-Dimethylthiazol-2-yl)-5-(3-Carboxymethoxyphenyl)-2-(4-Sulfophenyl)-2H-Tetrazolium Proliferation Assay to Overcome the Interference of Hydralazine
The MTS...
A year in the life of the EU-CardioRNA COST action: CA17129 catalysing transcriptomics research in cardiovascular disease
The EU-CardioRNA Cooperation in Science and Technology (COST) Action is a European-wide...
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele...
DNA copy number variations - Do these big mutations have a big effect on cardiovascular risk?
[No abstract available]
Highlights from the International Society of Hypertension's New Investigators Network during 2019
The New Investigators Committee (NIC) of the International Society of Hypertension (ISH) is a...
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
AIMS: Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute...
May measurement month 2019: The global blood pressure screening campaign of the international society of hypertension
Elevated blood pressure remains the single biggest risk factor contributing to the global burden...
Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice
BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic nervous...
The association between selected molecular biomarkers and ambulatory blood pressure patterns in African chronic kidney disease and hypertensive patients compared with normotensive controls: Protocol for a longitudinal study
Background: Chronic kidney disease (CKD) is a burgeoning epidemic in sub-Saharan Africa. Abnormal...
The prevalence of cardiovascular risk factors and cardiovascular disease among primary care patients in Poland: results from the LIPIDOGRAM2015 study
Background and aim: To estimate the prevalence of cardiovascular (CV) disease and CV risk factors...
Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis
Objective: The male-specific region of the Y chromosome (MSY) remains one of the most unexplored...
May Measurement Month 2017: Results of 39 national blood pressure screening programmes
Raised blood pressure is the biggest single risk factor responsible for mortality worldwide....
May measurement month 2018: A pragmatic global screening campaign to raise awareness of blood pressure by the international society of hypertension
Aims: Raised blood pressure (BP) is the biggest contributor to mortality and disease burden...
Renal nerves contribute to hypertension in Schlager BPH/2J mice
Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous...
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure...
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic...
Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics
Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is...
Are the American Heart Association/American college of cardiology high blood pressure guidelines fit for global purpose? Thoughts from the international society of hypertension
On the basis of currently available evidence, 1. We welcome the increased emphasis on...
Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies
Background: Even before the onset of age-related diseases, obesity might be a contributing factor...
Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive-a new preclinical model
Background--Among the growing numbers of patients with heart failure, up to one half have heart...
Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life
Background and aims: Fetal and postnatal growth restriction cause a predisposition to...
Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy
Hypertrophic cardiomyopathy thickens heart muscles, reducing functionality and increasing risk of...
May Measurement Month 2017: an analysis of blood pressure screening results worldwide
Background: Increased blood pressure is the biggest contributor to the global burden of disease...
Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney...
A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes
There is an increasing appreciation for the role of the human Y chromosome in phenotypic...
Cardiac telomere length in heart development, function, and disease
Telomeres are repetitive nucleoprotein structures at chromosome ends, and a decrease in the...
Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease
Circular RNAs in heart failure
Cardiovascular disease, and particularly heart failure, is still a serious health care issue for...
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure
BACKGROUND: Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular...
Genetics of blood pressure: Time to curate the collection
Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall
Background and aims Haplogroup I, a common European paternal lineage of the Y chromosome, is...
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease...
Is there a link between mitochondrial DNA and blood pressure?
[No abstract available]
Liraglutide and Renal Outcomes in Type 2 Diabetes
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide...
MicroRNAs in a hypertrophic heart: from foetal life to adulthood
The heart is the first organ to form and undergoes adaptive remodelling with age. Ventricular...
Telomeres, aging and exercise: Guilty by association?
Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA...
Telomeres, exercise and cardiovascular disease: finding the means to justify the ends
The y chromosome: A blueprint for men's health?
The Y chromosome has long been considered a genetic wasteland' on a trajectory to completely...
Age-related macular degeneration displays shortened telomere length indicating differential biological aging
No Abstract
A multi-omics glimpse into the biology of arterial stiffness
Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness
Endurance exercise improves cardiovascular health and reduces mortality risk. Augmentation index...
Circulating microRNAs and hypertension - from new insights into blood pressure regulation to biomarkers of cardiovascular risk
Hypertension is a leading cause of cardiovascular morbidity and mortality worldwide, yet the...
Coronary Artery Disease: Why We should Consider the Y Chromosome
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality globally....
Epigenetic changes in leukocytes after 8 weeks of resistance exercise training
Purpose Regular engagement in resistance exercise training elicits many health benefits including...
Epigenetic Modifications in Essential Hypertension
Essential hypertension (EH) is a complex, polygenic condition with no single causative agent....
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with...
Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres
Leukocyte telomeres shorten with age, and excessive shortening is associated with age-related...
KIDNEY TARGETED microRNA-181a MIMIC TREATMENT IN HYPERTENSIVE BPH/2J MICE
No Abstract
Telomere dynamics during aging in polygenic left ventricular hypertrophy
Short telomeres are associated with increased risk of cardiovascular disease. Here we studied...
Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training
Telomeres are tandem repeat DNA sequences located at distal ends of chromosomes that protect...
THE EFFECT OF GENES INVOLVED IN MONOGENIC HUMAN CARDIOMYOPATHIES IN A POLYGENIC MODEL OF CARDIAC HYPERTROPHY
NO Abstract
THE RENOPROTECTIVE ROLE OF MICRORNAS FROM FIBROSIS CAUSED BY UREMIC TOXINS AFTER MYOCARDIAL INFARCTION
No Abstract
Tripartitemotif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22
Background:Left ventricular (LV) hypertrophy is a risk factor for cardiovascular death, but the...
A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are...
Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise
Physical exercise has proven cardiovascular benefits, yet there is no clear understanding of the...
Contribution of microRNA to pathological fibrosis in cardiorenal syndrome: impact of uremic toxins
Progressive reduction in kidney function in patients following myocardial infarction (MI) is...
Editorial: Across the globe in 4months: Two International Society of Hypertension new investigator symposia in 2014
EFFECT OF RENAL DENERVATION ON BLOOD PRESSURE AND MICRORNA 181A IN HYPERTENSIVE SCHLAGER MICE
Objective: Hypertensive Schlager mice (BPH) are hypertensive due to an exaggerated contribution...
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity...
Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans
Aim: DNA methylation programs gene expression and is involved in numerous biological processes....
MicroRNAs in essential hypertension and blood pressure regulation
MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury
New genetic loci link adipose and insulin biology to body fat distribution
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic...
Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure
The fibroblast growth factor 1 (FGF1) gene is expressed primarily in the kidney and may...
Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages
Runs of homozygosity (ROHs) are recognized signature of recessive inheritance. Contributions of...
Signatures of miR-181a on the Renal Transcriptome and Blood Pressure
MicroRNA-181a binds to the 3' untranslated region of messenger RNA (mRNA) for renin, a...
The emerging role of non-coding RNA in essential hypertension and blood pressure regulation
Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be...
Acute Exercise Leads to Regulation of Telomere-Associated Genes and MicroRNA Expression in Immune Cells
Telomeres are specialized nucleoprotein structures that protect chromosomal ends from...
Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis
Objective: Amongst middle-aged men, haplogroup I is associated with approximate to 50% higher...
Exercise: Putting Action into Our Epigenome
Most human phenotypes are influenced by a combination of genomic and environmental factors....
Leukocyte telomere length variation due to DNA extraction method
BACKGROUND: Telomere length is indicative of biological age. Shorter telomeres have been...
Measurement of absolute copy number variation reveals association with essential hypertension
Background: The role of copy number variation (CNV) has been poorly explored in essential...
Report of the 3rd annual International Society of Hypertension New Investigator Symposium.
Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death
MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in posttranscriptional...
The Relation of Rapid Changes in Obesity Measures to Lipid Profile - Insights from a Nationwide Metabolic Health Survey in 444 Polish Cities
Objective: The impact of fast changes in obesity indices on other measures of metabolic health is...
A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice
Genetically hypertensive mice (BPH/2J) are hypertensive because of an exaggerated contribution of...
Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage
BACKGROUND: Caloric restriction is known to extend the lifespan of all organisms in which it has...
Early treatment to prevent hypertension: A laudable goal
[No abstract available]
Genetic mechanisms of vascular and renal damage
[No abstract available]
Leading the change: Second International Society of Hypertension New Investigators' Symposium
Longer Leukocyte Telomeres Are Associated with Ultra-Endurance Exercise Independent of Cardiovascular Risk Factors
Telomere length is recognized as a marker of biological age, and shorter mean leukocyte telomere...
Male-Specific Region of the Y Chromosome and Cardiovascular Risk: Phylogenetic Analysis and Gene Expression Studies
Objective Haplogroup I of male-specific region of the human Y chromosome is associated with 50%...
Salt Loading in Canola Oil Fed SHRSP Rats Induces Endothelial Dysfunction
This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt...
Urotensin-II System in Genetic Control of Blood Pressure and Renal Function
Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised...
A MicroRNA Guide for Clinicians and Basic Scientists: Background and Experimental Techniques
MicroRNAs (miRNAs) are short non-coding RNA molecules that are approximately 22 nucleotides in...
Editorial: Council for high blood pressure research/InterAmerican Society of Hypertension/International Society of Hypertension: First new investigators symposium at the High Blood Pressure Research 2011 scientific sessions
Editorial: Report of the first International Society of Hypertension (ISH) Trainee/new investigator symposium: A global hypertension initiative
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
Background A sexual dimorphism exists in the incidence and prevalence of coronary artery...
Telomere attrition is attenuated in ultra-marathon runners
The acute effects of intense cardiorespiratory exercise on human telomerase reverse transcriptase and sirtuin 6 expression in white blood cells
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet,...
Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs
The kidney has long been invoked in the etiology of essential hypertension. This could involve...
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive...
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We...
ISH Hypertension Future Leaders Group: A network for new investigators run by new investigators
[No abstract available]
Pathway Analysis Shows Association between FGFBP1 and Hypertension
Variants in the gene encoding fibroblast growth factor 1 (FGF1) co-segregate with familial...
The epithelial sodium channel γ-subunit gene and blood pressure: Family based association, renal gene expression, and physiological analyses
Variants in the gene encoding the gamma-subunit of the epithelial sodium channel (SCNN1G) are...
FGF21 signalling pathway and metabolic traits - genetic association analysis.
Fibroblast growth factor 21 (FGF21) is a novel master regulator of metabolic profile. The...
Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array.
Genetic determinants of blood pressure are poorly defined. We undertook a large-scale,...
Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure
Copy number variation has emerged recently as an important genetic mechanism leading to...
A Common Variant in Low-Density Lipoprotein Receptior Related Protein 6 Gene (LRP6) Is Associated with LDL-Cholesterol
OBJECTIVE-: A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was...
Association between lipid profile and circulating concentrations of estrogens in young men
Inverse Associations Between Androgens and Renal Function:The Young Men Cardiovascular Association(YMCA) Study
Background: Men exhibit higher risk of nondiabetic renal diseases than women. This male...
SLC2A9 is a high-capacity urate transporter in humans.
The pressure of finding human hypertension genes: New tools, old dilemmas
Researchers in hypertension genetics feel like they are left behind again. It always seems that...
Association studies in current cardiovascular genetics: functional variants, tags or both?
Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis.
Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene.
Glomerular hyperfiltration: a new marker of metabolic risk
Genetic information in the diagnosis and treatment of hypertension.
Genetics of human essential hypertension from single mutations to quantitative trait loci
Cardiovascular genomics and oxidative stress.
Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat.
Hypertension genetics under pressure
Association of the human Y chromosome with cholesterol levels in the general population.
Epistatic interaction between beta(2)-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension
Functional genomics in rodent models of hypertension.
Genetics of hypertension: lessons learnt from mendelian and polygenic syndromes.
Serum C-reactive protein and lipids in ultra-marathon runners
Cardiovascular diseases and G-protein beta3 subunit gene (GNB3) in the era of genomewide scans
Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting.
Complex events in the evolution of the human pseudoautosomal region 2 (PAR2).
Microarray analysis of rat chromosome 2 congenic strains
Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go?
Y is there a risk to being male?