Using RNA-Seq to determine the epigenetic effects on cardiac hypertrophy

An enlarged heart is the one of the main risk factors for many cardiovascular diseases. It is not clear which genes and transcripts are association with increased risk of cardiac hypertrophy. Our hypothesis is that non-coding RNA and / or the aberrant expression of long-non coding RNA (exciting new RNA molecules previously thought of as JUNK RNA) may be one of the drivers. We will be using next generation sequencing and a range of cutting-edge technologies to determine which long non-coding RNA are expressed on the heart. We will also investigate the epigenetic effects of exercise related to heart size and health.

Supervision: Prof Fadi Charchar (Principal), Prof Fergal Grace (Associate), Prof Stephen Harrap (University of Melbourne)

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