Collaborative Research Network (CRN)

Professor Fadi Charchar

Research leader

Federation University Australia

Fadi Charchar graduated from Melbourne University (PHD) 1998 and is currently Associate Dean (Research) at FedUni. He was a Wellcome Trust Research Fellow at University of Glasgow and a BHF Lecturer at the University of Leicester. His research interests centres on molecular genetics of complex disease. This includes the genetics of cardiovascular diseases, sexual dimorphism of cardiovascular risk and the contribution of changes in genomic structure to disease. He has recently been awarded the Okamoto Young Investigator prize for his research on the Y sex chromosome and coronary artery disease.

Curriculum vitae

Position title: Associate Dean (Research) Professor in Biomedical Science, Honorary Research Fellow, University of Melbourne,Honorary Research Fellow, University of Leicester

Education/training institution and location degree year(s) field of study: University of Melbourne BSc(Hons) 1993 Genetics/Physiology,University of Melbourne PhD 1998 Genetics/Physiology

Positions and honours

Positions and employment

1998-2000  Postdoctoral Research Fellow/Lecturer – La Trobe University- Genetics

2000-2005 Wellcome Trust Travelling Research Fellow – University of Glasgow -Division of Cardiovascular and Medical Sciences

2005-2007 BHF Lecturer in Cardiovascular Science, University of Leicester-Division of Cardiovascular and Medical Sciences

2007-2008 Lecturer in Molecular Medicine, Barts and The London, William Harvey Research Centre

Other experience and professional memberships

2000-present Member of the Genetics Society of Australia

2001-present European Society of Hypertension

2001-present Society of Endocrinology

2005-present Fellow of the American Heart Association

Honours

2001  Graham Wilson Travel Award

2001-2004  Wellcome Trust Travelling Research Fellowship

2002 Basic Science Review Lecture Prize, presented at The Royal College of Physicians, London, 3–5 November 2003

2003 Howard Florey Centenary Fellowship

2005 European Fellow Travel Award from the American Heart Association

2008 Okamoto Young Investigator Prize

Major research achievements

Fadi Charchar graduated from The University of Melbourne a PhD in 1998. Ever since, he has been an active researcher in the field of cardiovascular genetics. Dr Charchar has worked with the leading investigators in the fields of genetics and complex disease. This has included PhD training with Prof Stephen Harrap in Australia and a Wellcome Trust Fellowship working in the BHF cardiovascular Research Centre Glasgow in the UK. During his time in the UK he has been involved in research on the involvement of the Y chromosome and cardiovascular disease showing for the first time that the Y harbours genes affecting the male cardiovascular system.

Selected peer-reviewed publications (in chronological order)

1. Kapuscinski M, Charchar F, Innes B, Mitchell GA, Norman TL, Harrap SB. Nervegrowth factor gene and hypertension in spontaneously hypertensive rats. J Hypertens. 1996; 14: 191-197.

2. Kapuscinski MK, Nemoto K, Ueyama T, Charchar F, Kageyama H, Fukumachi K, Sekimoto M, Senba E, Tomita T, Tomita I, Harrap SB. Low affinity nerve growth factor receptor gene co-segregates with decreased bodyweight and increased left ventricular weight in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1996; 23: 614-616.

3. Charchar FJ, Kapuscinski M, Harrap SB. Persistent reduction in renal nerve growth factor mRNA after perindopril treatment of young spontaneously hypertensive rats. Hypertension. 1998; 31: 678-683.

4. Charchar FJ, Kapuscinski MK, Harrap SB. Nerve growth factor gene locus explains elevated renal nerve growth factor mRNA in young spontaneously hypertensive rats. Hypertension. 1998; 32: 705-709.

5. Charchar FJ, Svartman M, Graves JA. Assignment of SPROUTY 1 (SPRY1) gene to tammar wallaby chromosome 6 by fluorescence in situ hybridisation. Cytogenet Cell Genet. 2000; 90: 240-241.

6. Charchar FJ, Tomaszewski M, Padmanabhan S, Lacka B, Upton MN, Inglis GC, Anderson NH, McConnachie A, Zukowska-Szczechowska E, Grzeszczak W, Connell JM, Watt GC, Dominiczak AF. The Y chromosome effect on blood pressure in two European populations. Hypertension. 2002; 39: 353-356.

7. Tomaszewski M, Brain NJ, Charchar FJ, Wang WY, Lacka B, Padmanabahn S, Clark JS, Anderson NH, Edwards HV, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension. 2002; 40: 286-291.

8. Charchar FJ, Svartman M, El-Mogharbel N, Ventura M, Kirby P, Matarazzo MR, Ciccodicola A, Rocchi M, D'Esposito M, Graves JA. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Genome Res. 2003; 13: 281-286.

9. Charchar FJ, Tomaszewski M, Strahorn P, Champagne B, Dominiczak AF. Y is there a risk to being male? Trends Endocrinol Metab. 2003; 14: 163-168.

10. McBride MW, Carr FJ, Graham D, Anderson NH, Clark JS, Lee WK, Charchar FJ, Brosnan MJ, Dominiczak AF. Microarray analysis of rat chromosome 2 congenic strains. Hypertension. 2003; 41: 847-853.

11. Tomaszewski M, Charchar FJ, Przybycin M, Crawford L, Wallace AM, Gosek K, Lowe GD, Zukowska-Szczechowska E, Grzeszczak W, Sattar N, Dominiczak AF. Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go? Arterioscler Thromb Vasc Biol. 2003; 23: 1640-1644.

12. Charchar FJ, Tomaszewski M, Lacka B, Zakrzewski J, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Association of the human Y chromosome with cholesterol levels in the general population. Arterioscler Thromb Vasc Biol. 2004; 24: 308-312.

13. Tomaszewski M, Charchar FJ, Crawford L, Zukowska-Sczechowska E, Grzeszczak W, Sattar N, Dominiczak AF. Serum C-reactive protein and lipids in ultra-Marathon runners. Am J Cardiol. 2004; 94: 125-126.

14. Tomaszewski M, Charchar FJ, Lacka B, Pesonen U, Wang WY, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Hypertension. 2004; 44: 689-694.

15. Strahorn P, Graham D, Charchar FJ, Sattar N, McBride MW, Dominiczak AF. Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. J Hypertens. 2005; 23: 2179-2186.

16. Tomaszewski M, Moreno MU, Charchar FJ, Zukowska-Szczechowska E, Dominiczak AF. Functional significance of single nucleotide polymorphisms within the 5′-flanking region of beta2-adrenergic receptor gene. J Hypertens. 2006; 24: 2473-4; author reply 2474-6.

17. Tomaszewski M, Zimmerli L, Charchar FJ, Dominiczak AF. Genetic information in the diagnosis and treatment of hypertension. Curr Hypertens Rep. 2006; 8: 309-316.

18. Clemitson JR, Dixon RJ, Haines S, Bingham AJ, Patel BR, Hall L, Lo M, Sassard J, Charchar FJ, Samani NJ. Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene. Circ Res. 2007; 100: 992-999.

19. Charchar FJ, Shankar RR, Eckert GJ, Saha C, Tu W, Dominiczak AF, Pratt JH. Studies of an association in boys of blood pressure and the Y chromosome. Am J Hypertens. 2007; 20: 27-31.

20. Tomaszewski M, Charchar FJ, Lynch MD, Padmanabhan S, Wang WY, Miller WH, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak AF. Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation. 2007; 116: 1915-1924.

21. Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L, Grzeszczak W, Sattar N, Zukowska-Szczechowska E, Dominiczak AF. Glomerular hyperfiltration: a new marker of metabolic risk. Kidney Int. 2007; 71: 816-821.

22. Tomaszewski M, Charchar FJ, Samani NJ. Association studies in current cardiovascular genetics – functional variants, tags or both? J Hum Hypertens. 2007; 21: 425-426.

23. Charchar FJ, Zimmerli L, Tomaszewski M. The Pressure of Finding Human Hypertension Genes – new tools, old dilemmas. J Hum Hypertens. 2008 2(12):821-8.

24. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ et al. SLC2A9 is a high-capacity urate transporter in humans. 2008 PLoS Med.5(10):e197-207.

25. Tomaszewski M, Charchar FJ, Maric C, Kuzniewicz R, Gola M, Grzeszczak W, Samani NJ, Zukowska-Szczechowska E. Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study. Am J Hypertens. 2009 22(1):100-5.

26. Tomaszewski M, Charchar FJ, Barnes T, Gawron-Kiszka M, Sedkowska A, Podolecka E, Kowalczyk J, Rathbone W, Kalarus Z, Grzeszczak W, Goodall AH, Samani NJ, Zukowska-Szczechowska E. A common variant in low-density lipoprotein receptor related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol. 2009 29(9):1316-21.

27. Charchar FJ, Kaiser M, Bingham AJ, Fotinatos N, Ahmady F, Tomaszewski M, Samani NJ. Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure. Hypertension. 2010 55(5):1231-8.

28. International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 11;478(7367)

29. Charchar FJ, Bloomer L, Barnes TA, Cowley M, Nelson C, Wang Y, Denniff M, Debiec R, Christofidou P, Nankervis S, Dominiczak AF, Bani-Mustafa A, Balmforth AJ, Hall AS , Erdmann J, Cambien F, Deloukas P, Hengstenberg C, Packard C, Schunkert H, Ouwehand W, Ford I, Goodall AH, Jobling MA, Samani NJ and Tomaszewski M. New insights into inheritance of coronary artery disease in men- the role of the Y sex chromosome. The Lancet 2012 (in press).