Faculty of Science and Technology

Prof Fadi Charchar

Position: Emeritus Robert HT Smith Chair in Cardiovascular Science
Phone: (03) 5327 6098
Email: f.charchar@federation.edu.au
Room: Y 117

Qualifications

  • BSc (Hons)
  • PhD (Melb)
  • FAHA

Teaching areas

  • Genomics
  • Biomedical research
  • Molecular biology

Professional associations

  • International Society of Hypertension
  • Cardiac Society of Australia and New Zealand
  • European Society of Hypertension
  • American Heart Association

Grants and awards

  • NHMRC - Genetics of Cardiac Hypertrophy
  • NHMRC - Copy Number Variation and Hypertension
  • British Heart Foundation - The Y chromosome and cardiovascular disease
  • National Heart Foundation - Hypertrophy and MicroRNA
  • LEW CARTY Charitable Foundation
  • Helen MacPherson Smith Trust

Research interests

Cardiovascular or heart disease is the predominant cause of human morbidity and mortality in developed countries. A big heart and high blood pressure are bad news, no matter what the cause. These two diseases are both major risk factors for cardiovascular disease and Professor Fadi Charchar's laboratory's effort is devoted to determining the molecular and pathophysiological characteristics of both with the goal of developing novel diagnostic and therapeutic. We are using a model of human heart enlargement that has a genetic cause in collaboration with the University of Melbourne and we also have a large collection of human cohorts and kidney tissue bank in collaboration with universities worldwide. Our recent studies have shown that a novel class of small noncoding RNAs, called microRNSs (miRNAs) are possible contributors to hypertension and enlarged hearts. We are also part of The International Consortium for Blood Pressure Genome-Wide Association Studies (Nature, 2011) We have a special interest in the Y chromosome and disease.

Examples of supervised projects

  1. Non-coding RNA and Cardiovascular Disease
  2. The effect of exercise on telomeres and microRNA
  3. The Y chromosome and heart disease

Publications

  1. Molina E, Clarence EM, Ahmady F, Chew GS, Charchar FJ. Coronary Artery Disease: Why we should consider the Y Chromosome. Heart, Lung & Circulation. 2016 Jan; doi: http://dx.doi.org/10.1016/j.hlc.2015.12.100
  2. Marques FZ, Booth SA, Charchar FJ. The emerging role of non-coding RNA in essential hypertension and blood pressure regulation. J Hum Hypertens. 2014 Nov 13. doi: 10.1038/jhh.2014.99
  3. Skommer J, Rana I, Marques FZ, Zhu W, Du Z, Charchar FJ. Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death. Cell Death Dis. 2014 Jul 17;5:e1325. doi: 10.1038/cddis.2014.287. Review.
  4. Marques FZ, Prestes PR, Pinheiro LB, Scurrah K, Emslie KR, Tomaszewski M, Harrap SB, Charchar FJ. Measurement of absolute copy number variation reveals association with essential hypertension. BMC Med Genomics. 2014 Jul 15;7:44. doi: 10.1186/1755-8794-7-44
  5. Chilton WL, Marques FZ, West J, Kannourakis G, Berzins SP, O'Brien BJ, Charchar FJ. Acute Exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One. 2014 Apr 21;9(4):e92088. doi: 10.1371/journal.pone.0092088.
  6. Bloomer LD, Nelson CP, Denniff M, Christofidou P, Debiec R, Thompson J, Zukowska-Szczechowska E, Samani NJ, Charchar FJ, Tomaszewski M. Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids--genetic association analysis. Atherosclerosis. 2014 Mar;233(1):160-4. doi: 10.1016/j.atherosclerosis.2013.12.012.
  7. Kaess BM, J????wiak J, Nelson CP, Lukas W, Mastej M, Windak A, Tomasik T, Grzeszczak W, Tykarski A, G??sowski J, ??l??zak-Prochazka I, ??l??zak A, Charchar FJ, Sattar N, Thompson JR, Samani NJ, Tomaszewski M. The relation of rapid changes in obesity measures to lipid profile - insights from a nationwide metabolic health survey in 444 Polish cities. PLoS One. 2014 Jan 31;9(1):e86837. doi: 10.1371/journal.pone.0086837.
  8. Nankervis SA, Mitchell JM, Charchar FJ, McGlynn MA, Lewandowski PA. Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage. Longev Healthspan. 2013 Mar 1;2(1):4. doi: 10.1186/2046-2395-2-4.
  9. Debiec R, Christofidou P, Denniff M, Bloomer LD, Bogdanski P, Wojnar L, Musialik K, Charchar FJ, Thompson JR, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Samani NJ, Lambert D, Tomaszewski M. Urotensin-II system in genetic control of blood pressure and renal function. PLoS One. 2013 Dec 31;8(12):e83137. doi: 10.1371/journal.pone.0083137.
  10. Burger D, Veerabhadrappa P, Charchar FJ, Schutte AE, Tomaszewski M. Report of the 3rd annual International Society of Hypertension New Investigator Symposium. J Hypertens. 2014 Feb;32(2):448-9. doi: 10.1097/HJH.0000000000000087.
  11. Harrap SB, Charchar FJ. Early treatment to prevent hypertension: a laudable goal. Am J Hypertens. 2013 Dec;26(12):1367-8. doi: 10.1093/ajh/hpt193.
  12. Denham J, Marques FZ, O'Brien BJ, Charchar FJ. Exercise: putting action into our epigenome. Sports Med. 2014 Feb;44(2):189-209. doi: 10.1007/s40279-013-0114-1.
  13. Marques FZ, Tomaszewski M, Charchar FJ. Genetic mechanisms of vascular and renal damage. J Hypertens. 2013 Nov;31(11):2128-9. doi: 10.1097/HJH.0b013e3283654187.
  14. Denham J, Nelson CP, O'Brien BJ, Nankervis SA, Denniff M, Harvey JT, Marques FZ, Codd V, Zukowska-Szczechowska E, Samani NJ, Tomaszewski M, Charchar FJ. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors. PLoS One. 2013 Jul 31;8(7):e69377. doi: 10.1371/journal.pone.0069377.
  15. Jackson KL, Marques FZ, Watson AM, Palma-Rigo K, Nguyen-Huu TP, Morris BJ, Charchar FJ, Davern PJ, Head GA. A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice. Hypertension. 2013 Oct;62(4):775-81. doi: 10.1161/HYPERTENSIONAHA.113.01701.
  16. Papazzo A, Conlan XA, Lexis L, Charchar FJ, Lewandowski PA. Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction. PLoS One. 2013 Jun 7;8(6):e66655. doi: 10.1371/journal.pone.0066655.
  17. Bloomer LD, Nelson CP, Eales J, Denniff M, Christofidou P, Debiec R, Moore J, Consortium C, Zukowska-Szczechowska E, Goodall AH, Thompson J, Samani NJ, Charchar FJ, Tomaszewski M. Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1722-7. doi: 10.1161/ATVBAHA.113.301608.
  18. Veerabhadrappa P, Charchar FJ, Burger D, Tomaszewski M, Carlberg B. Leading the change: Second International Society of Hypertension New Investigators' Symposium. J Hypertens. 2013 Feb;31(2):429-30. doi: 10.1097/HJH.0b013e32835c552c.
  19. Charchar FJ, Bloomer LD, Barnes TA, Cowley MJ, Nelson CP, Wang Y, Denniff M, Debiec R, Christofidou P, Nankervis S, Dominiczak AF, Bani-Mustafa A, Balmforth AJ, Hall AS, Erdmann J, Cambien F, Deloukas P, Hengstenberg C, Packard C, Schunkert H, Ouwehand WH, Ford I, Goodall AH, Jobling MA, Samani NJ, Tomaszewski M. Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet. 2012 Mar 10;379(9819):915-22. doi: 10.1016/S0140-6736(11)61453-0.
  20. Burger D, Veerabhadrappa P, Charchar FJ, Tomaszewski M, Harrap S, Carlberg B, Touyz RM. Report of the first International Society of Hypertension (ISH) Trainee/New Investigator Symposium: A Global Hypertension Initiative. J Hypertens. 2012 Mar;30(3):631-2. doi: 10.1097/HJH.0b013e32834f8267.
  21. Bernardo BC, Charchar FJ, Lin RC, McMullen JR. A microRNA guide for clinicians and basic scientists: background and experimental techniques. Heart Lung Circ. 2012 Mar;21(3):131-42. doi: 10.1016/j.hlc.2011.11.002.
  22. Veerabhadrappa P, Burger D, Charchar F, Tomaszewski M, Carlberg B, Harrap S, Touyz RM. Council for [corrected] High Blood Pressure Research/InterAmerican Society of Hypertension/International Society of Hypertension: [corrected] first New Investigators Symposium at the High Blood Pressure Research 2011 Scientific Sessions. Hypertension. 2012 Feb;59(2):382-3. doi: 10.1161/HYPERTENSIONAHA.111.185421.
  23. Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ. Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs. Hypertension. 2011 Dec;58(6):1093-8. doi: 10.1161/HYPERTENSIONAHA.111.180729.
  24. B??sst CJ, Bloomer LD, Scurrah KJ, Ellis JA, Barnes TA, Charchar FJ, Braund P, Hopkins PN, Samani NJ, Hunt SC, Tomaszewski M, Harrap SB. The epithelial sodium channel ??-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses. Hypertension. 2011 Dec;58(6):1073-8. doi: 10.1161/HYPERTENSIONAHA.111.176370.
  25. Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, K??hnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, D??ring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hypp??nen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, K??hn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, W??rtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietil??inen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, V??lzke H, Schadt EE, Scott J, J??rvelin MR, Elliott P, Kooner JS. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970.
  26. International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, S??ber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WH, Sj??gren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen KD, Lehtim??ki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CS, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium, Aspelund T, Garcia M, Chang YP, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day IN, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Hopewell JC, Ongen H, Dreisbach AW, Li Y, Young JH, Bis JC, K??h??nen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Bolton JA, K??ttgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Gr??ssler J, Groop L, Voight BF, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw KT, Weder AB, Hunt SC, Sun YV, Bergman RN, Collins FS, Bonnycastle LL, Scott LJ, Stringham HM, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Soler Artigas M, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann HE, Cho YS, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang W, Hedblad B, Nilsson P, Smith GD, Wong A, Narisu N, Stan????kov?? A, Raffel LJ, Yao J, Kathiresan S, O'Donnell CJ, Schwartz SM, Ikram MA, Longstreth WT Jr, Mosley TH, Seshadri S, Shrine NR, Wain LV, Morken MA, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJ, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Hofman A, Mattace-Raso FU, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytik??inen LP, Soininen P, Tukiainen T, W??rtz P, Ong RT, D??rr M, Kroemer HK, V??lker U, V??lzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar MV, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FG, Charchar FJ, Schwarz PE, Hayward C, Guo X, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Hveem K, Palmer LJ, van der Schouw YT, Casas JP, Mohlke KL, Vineis P, Raitakari O, Ganesh SK, Wong TY, Tai ES, Cooper RS, Laakso M, Rao DC, Harris TB, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu X, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Wilson JF, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands EJ, Altshuler D, Loos RJ, Shuldiner AR, Gieger C, Meneton P, Uitterlinden AG, Wareham NJ, Gudnason V, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JC, Hartikainen AL, Beckmann JS, Boerwinkle E, Vasan RS, Boehnke M, Larson MG, J??rvelin MR, Psaty BM, Abecasis GR, Chakravarti A, Elliott P, van Duijn CM, Newton-Cheh C, Levy D, Caulfield MJ, Johnson T. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9. doi: 10.1038/nature10405.
  27. Veerabhadrappa P, Burger D, Carlberg B, Charchar FJ, Tomaszewski M, Harrap S; New Investigators Committee, International Society of Hypertension. ISH Hypertension Future Leaders Group: a network for new investigators run by new investigators. J Hypertens. 2011 Aug;29(8):1664-5. doi: 10.1097/HJH.0b013e3283491598.
  28. Tomaszewski M, Charchar FJ, Nelson CP, Barnes T, Denniff M, Kaiser M, Debiec R, Christofidou P, Rafelt S, van der Harst P, Wang WY, Maric C, Zukowska-Szczechowska E, Samani NJ. Pathway analysis shows association between FGFBP1 and hypertension. J Am Soc Nephrol. 2011 May;22(5):947-55. doi: 10.1681/ASN.2010080829.
  29. Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1;20(11):2273-84. doi: 10.1093/hmg/ddr092.
  30. Tomaszewski M, Debiec R, Braund PS, Nelson CP, Hardwick R, Christofidou P, Denniff M, Codd V, Rafelt S, van der Harst P, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Burton PR, Mooser V, Charchar FJ, Thompson JR, Tobin MD, Samani NJ. Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension. 2010 Dec;56(6):1069-76. doi: 10.1161/HYPERTENSIONAHA.110.155721.
  31. Kaess BM, Barnes TA, Stark K, Charchar FJ, Waterworth D, Song K, Wang WY, Vollenweider P, Waeber G, Mooser V, Zukowska-Szczechowska E, Samani NJ, Hengstenberg C, Tomaszewski M. FGF21 signalling pathway and metabolic traits - genetic association analysis. Eur J Hum Genet. 2010 Dec;18(12):1344-8. doi: 10.1038/ejhg.2010.130.
  32. Charchar FJ, Kaiser M, Bingham AJ, Fotinatos N, Ahmady F, Tomaszewski M, Samani NJ. Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure. Hypertension. 2010 May;55(5):1231-8. doi: 10.1161/HYPERTENSIONAHA.109.141663.
  33. Tomaszewski M, Charchar FJ, Barnes T, Gawron-Kiszka M, Sedkowska A, Podolecka E, Kowalczyk J, Rathbone W, Kalarus Z, Grzeszczak W, Goodall AH, Samani NJ, Zukowska-Szczechowska E. A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1316-21. doi: 10.1161/ATVBAHA.109.185355.
  34. Tomaszewski M, Charchar FJ, Maric C, Kuzniewicz R, Gola M, Grzeszczak W, Samani NJ, Zukowska-Szczechowska E. Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study. Am J Hypertens. 2009 Jan;22(1):100-5. doi: 10.1038/ajh.2008.307.
  35. Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson RJ, Wallace C, Newhouse SJ, Brown M, Connell JM, Dominiczak A, Farrall M, Lathrop GM, Samani NJ, Kumari M, Marmot M, Brunner E, Chambers J, Elliott P, Kooner J, Laan M, Org E, Veldre G, Viigimaa M, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Moley KH, Cheeseman C. SLC2A9 is a high-capacity urate transporter in humans. PLoS Med. 2008 Oct 7;5(10):e197. doi: 10.1371/journal.pmed.0050197.
  36. Tomaszewski M, Charchar FJ, Maric C, Kuzniewicz R, Gola M, Grzeszczak W, Samani NJ, Zukowska-Szczechowska E. Association between lipid profile and circulating concentrations of estrogens in young men. Atherosclerosis. 2009 Mar;203(1):257-62. doi: 10.1016/j.atherosclerosis.2008.06.002.
  37. Tomaszewski M, Charchar FJ, Lynch MD, Padmanabhan S, Wang WY, Miller WH, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak AF. Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation. 2007 Oct 23;116(17):1915-24.
  38. Clemitson JR, Dixon RJ, Haines S, Bingham AJ, Patel BR, Hall L, Lo M, Sassard J, Charchar FJ, Samani NJ. Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifies SPON1 as a novel candidate hypertension gene. Circ Res. 2007 Apr 13;100(7):992-9.
  39. Shankar RR, Charchar FJ, Eckert GJ, Saha C, Tu W, Dominiczak AF, Pratt JH. Studies of an association in boys of blood pressure and the Y chromosome. Am J Hypertens. 2007 Jan;20(1):27-31.
  40. Tomaszewski M, Moreno MU, Charchar FJ, Zukowska-Szczechowska E, Dominiczak AF. Functional significance of single nucleotide polymorphisms within the 5'-flanking region of beta2-adrenergic receptor gene. J Hypertens. 2006 Dec;24(12):2473-4.
  41. Tomaszewski M, Zimmerli L, Charchar FJ, Dominiczak AF. Genetic information in the diagnosis and treatment of hypertension. Curr Hypertens Rep. 2006 Aug;8(4):309-16. Review.
  42. Strahorn P, Graham D, Charchar FJ, Sattar N, McBride MW, Dominiczak AF. Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. J Hypertens. 2005 Dec;23(12):2179-86.
  43. Tomaszewski M, Charchar FJ, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Letter re: Inflammation and lipoprotein changes with protracted exercise. J Clin Endocrinol Metab. 2005 Aug;90(8):4981.
  44. Dominiczak AF, Brain N, Charchar FJ, McBride M, Hanlon N, Lee WK. Genetics of hypertension: lessons learnt from mendelian and polygenic syndromes. Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):611-20. Review.
  45. Dominiczak AF, Graham D, McBride MW, Brain NJ, Lee WK, Charchar FJ, Tomaszewski M, Delles C, Hamilton CA. Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension. 2005 Apr;45(4):636-42.
  46. Tomaszewski M, Charchar FJ, Lacka B, Pesonen U, Wang WY, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Hypertension. 2004 Nov;44(5):689-94.
  47. Tomaszewski M, Charchar FJ, Crawford L, Zukowska-Sczechowska E, Grzeszczak W, Sattar N, Dominiczak AF. Serum C-reactive protein and lipids in ultra-Marathon runners. Am J Cardiol. 2004 Jul 1;94(1):125-6.
  48. Charchar FJ, Tomaszewski M, Lacka B, Zakrzewski J, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Association of the human Y chromosome with cholesterol levels in the general population. Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):308-12.
  49. McBride MW, Charchar FJ, Graham D, Miller WH, Strahorn P, Carr FJ, Dominiczak AF. Functional genomics in rodent models of hypertension. J Physiol. 2004 Jan 1;554(Pt 1):56-63. Review.
  50. Tomaszewski M, Charchar FJ, Przybycin M, Crawford L, Wallace AM, Gosek K, Lowe GD, Zukowska-Szczechowska E, Grzeszczak W, Sattar N, Dominiczak AF. Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go? Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1640-4.
  51. Charchar FJ, Tomaszewski M, Strahorn P, Champagne B, Dominiczak AF. Y is there a risk to being male? Trends Endocrinol Metab. 2003 May-Jun;14(4):163-8. Review.
  52. Chapman MA, Charchar FJ, Kinston S, Bird CP, Grafham D, Rogers J, Gr??tzner F, Graves JA, Green AR, G??ttgens B. Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting. Genomics. 2003 Mar;81(3):249-59.
  53. McBride MW, Carr FJ, Graham D, Anderson NH, Clark JS, Lee WK, Charchar FJ, Brosnan MJ, Dominiczak AF. Microarray analysis of rat chromosome 2 congenic strains. Hypertension. 2003 Mar;41(3 Pt 2):847-53.
  54. Charchar FJ, Svartman M, El-Mogharbel N, Ventura M, Kirby P, Matarazzo MR, Ciccodicola A, Rocchi M, D'Esposito M, Graves JA. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Genome Res. 2003 Feb;13(2):281-6.
  55. Tomaszewski M, Brain NJ, Charchar FJ, Wang WY, Lacka B, Padmanabahn S, Clark JS, Anderson NH, Edwards HV, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension. 2002 Sep;40(3):286-91.
  56. Carr FJ, McBride MW, Carswell HV, Graham D, Strahorn P, Clark JS, Charchar FJ, Dominiczak AF. Genetic aspects of stroke: human and experimental studies. J Cereb Blood Flow Metab. 2002 Jul;22(7):767-73. Review.
  57. McBride MW, Carswell HV, Graham D, Carr FJ, Charchar FJ, Macrae IM, Dominiczak AF. Genetic and gender determinants of cerebrovascular disease. Semin Nephrol. 2002 Mar;22(2):127-34. Review.
  58. Charchar FJ, Tomaszewski M, Padmanabhan S, Lacka B, Upton MN, Inglis GC, Anderson NH, McConnachie A, Zukowska-Szczechowska E, Grzeszczak W, Connell JM, Watt GC, Dominiczak AF. The Y chromosome effect on blood pressure in two European populations. Hypertension. 2002 Feb;39(2 Pt 2):353-6.